tailieunhanh - Báo cáo "Study of Dracaena angustifolia : I - New spirostanol sapogenins from roots and rhizomes "

Dracaena angustifolia Roxb. (Dracaenaceae) is locally known as Nam ginseng (ginseng from the South) in Quang Nam province. Its underground parts are used as tonic and for treatment of In our continuing studies on Vietnamese medicinal plants, we have examined the constituents of Nam ginseng (D. angustifolia) and isolated three new spirostanol sapogenins. This paper reports the isolation and structure elucidation of these new compounds. | Journal of Chemistry Vol. 42 1 P. 122 -124 2004 STUDY OF DRACAENA ANGUSTIFOLIA I - NEW SPIROSTANOL SAPOGENINS FROM ROOTS AND RHIZOMES Received 15-1-2003 TRAN LE QUAN 1 TRAN KIM QUI 1 SHIGETOSHI KADOTA2 College of Natural Sciences National University-Hochiminh City Hochiminh City Institute of Natural Medicine Toyama Medical Pharmaceutical University Toyama Japan Địa chỉ liờn lạc GS. TS. Trần Kim Qui Trường Đại học Khoa học Tự nhiên Tp. HCM. 55D Trần Phú Tp. HCM Điện thoại 08-835-4421 SUMMARY The MeOH extract of Nam ginseng roots and rhizomes of Dracaena angustifolia afforded three new spirostanol sapogenins named namogenins A-C 1-3 . Their structures were determined on basis of spectral analyses and chemical methods. I. INTRODUCTION Dracaena angustifolia Roxb. Dracaenaceae is locally known as Nam ginseng ginseng from the South in Quang Nam province. Its underground parts are used as tonic and for treatment of In our continuing studies on Vietnamese medicinal plants we have examined the constituents of Nam ginseng D. angustifolia and isolated three new spirostanol sapogenins. This paper reports the isolation and structure elucidation of these new compounds. 122 II. RESULTS AND DISCUSSION Air-dried roots and rhizomes of D. angustifolia were extracted successively by refluxing MeOH 50 aqueous MeOH and water to give MeOH MeOH-H2O and H2O extracts respectively. The MeOH extract was subjected to Diaion HP-20 column chromatography CC . The MeOH eluate was further separated by a combination of silica gel and ODS column chromatographies and normal- and reversed-phase pTLC to afford three new compounds named namogenins A-C 1-3 . Negative-ion HRFABMS of 1 displayed a quasi-molecular ion at m z indicating the molecular formula C27H42O6. The 1H NMR spectrum of 1 showed signals ascribable to two tertiary methyls and three secondary methyls while the 13C NMR spectrum of 1 showed thirty-five signals Table 1 . Analysis of the COSY and HMQC spectra together .