tailieunhanh - Báo cáo khoa học: Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP)

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a recently described Ca 2+ mobilizing messenger, and probably the most potent. We briefly review its unique properties as a Ca 2+ mobilizing agent. We present arguments for its action in targeting acidic calcium stores rather than the endoplasmic reticulum. Finally, we discuss possible biosynthetic pathways for NAADP in cells and candidates for its target Ca 2+ release channel, which has eluded identification so far. | iFEBS Journal MINIREVIEW Calcium signalling by nicotinic acid adenine dinucleotide phosphate NAADP Michiko Yamasaki Grant C. Churchill and Antony Galione Department of Pharmacology University of Oxford UK Keywords acidic stores cADPR endoplasmic reticulum InsP3 NAADP Correspondence A. Galione Department of Pharmacology University of Oxford Mansfield Road Oxford OX1 3QT UK Fax 44 1865 271853 Tel 44 1865 271633 E-mail Received 28 April2005 accepted 30 June 2005 doi Nicotinic acid adenine dinucleotide phosphate NAADP is a recently described Ca2 mobilizing messenger and probably the most potent. We briefly review its unique properties as a Ca2 mobilizing agent. We present arguments for its action in targeting acidic calcium stores rather than the endoplasmic reticulum. Finally we discuss possible biosynthetic pathways for NAADP in cells and candidates for its target Ca2 release channel which has eluded identification so far. Intracellular Ca2 signals are coordinated to elicit spatiotemporal patterns. These include repetitive Ca2 transients which may be localized or propagated as regenerative waves that may also pass into neighbouring cells 1-3 . D-myo-Inositol 1 4 5-trisphosphate InsP3 is a well-established intracellular Ca2 mobilizing messenger in many cell types 3 and is a paradigm for additional molecules that release Ca2 from intracellular Ca2 stores. Cyclic ADP-ribose cADPR and nicotinic acid adenine dinucleotide phosphate NAADP were first discovered in the sea urchin egg as novel Ca2 mobilizing agents 4-6 . In this cell cADPR was shown to target ryanodine receptors RyRs to release Ca2 from the endoplasmic reticulum ER and now has been established as an intracellular messenger in several cell types 7 8 . In contrast NAADP was found to activate a Ca2 release mechanism distinct from those activated by InsP3 and cADPR based on pharmacology and self-induced inactivation of the different Ca2 release .

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