tailieunhanh - Báo cáo khoa học: Mitochondrial calcium signalling in cell death Delivered on 1 July 2004 at the 29th FEBS Congress in Warsaw

The development of targeted probes (based on the molecular engineering of luminescent or fluorescent proteins) has allowed the specific measure-ment of [Ca 2+ ] in intracellular organelles or cytoplasmic subdomains. This approach gave novel information on different aspects of cellular Ca 2+ homeostasis. Regarding mitochondria, it was possible to demonstrate that, upon physiological stimulation of cells, Ca 2+ is rapidly accumulated in the matrix. | ềFEBS Journal THE THEODOR BUCHER LECTURE Mitochondrial calcium signalling in cell death Delivered on 1 July 2004 at the 29th FEBS Congress in Warsaw Sara Leo1 Katiuscia Bianchi1 Marisa Brini2 and Rosario Rizzuto1 1 Department of Experimentaland Diagnostic Medicine Section of GeneralPathology and Interdisciplinary Center for the Study of Inflammation ICSI University of Ferrara Italy 2 Department of Biochemistry University of Padova Italy Keywords apoptosis calcium mitochondria organelles photoproteins signal transduction Correspondence R. Rizzuto Department of Experimental and Diagnostic Medicine GeneralPathology Section University of Ferrara Via L. Borsari 46 44100 Ferrara Italy Fax 39 0532247278 Tel 39 0532291361 E-mail The development of targeted probes based on the molecular engineering of luminescent or fluorescent proteins has allowed the specific measurement of Ca2 in intracellular organelles or cytoplasmic subdomains. This approach gave novel information on different aspects of cellular Ca2 homeostasis. Regarding mitochondria it was possible to demonstrate that upon physiological stimulation of cells Ca2 is rapidly accumulated in the matrix. We will discuss the basic characteristics of this process its role in modulating physiological and pathological events such as the regulation of aerobic metabolism and the induction of cell death and new insight into the regulatory mechanisms operating in vivo. Received 1 June 2005 accepted 11 July 2005 doi In the last few decades much information has been obtained on the role of calcium ions as ubiquitous second messengers that translate the binding of signalling molecules to plasmamembrane receptors into defined cell activities 1 . Thanks to the development of highly efficient probes the intracellularly trappable fluorescent indicators developed by Tsien and coworkers 2 it was possible to investigate the calcium signals elicited in a wide variety of cell types either

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