tailieunhanh - Báo cáo khoa học: Flexible nets The roles of intrinsic disorder in protein interaction networks

Proteins participate in complex sets of interactions that represent the mech-anistic foundation for much of the physiology and function of the cell. These protein–protein interactions are organized into exquisitely complex networks. The architecture of protein–protein interaction networks was recently proposed to be scale-free, with most of the proteins having only one or two connections but with relatively fewer ‘hubs’ possessing tens, hundreds or more links. | ềFEBS Journal MINIREVIEW Flexible nets The roles of intrinsic disorder in protein interaction networks A. Keith Dunker1 Marc S. Cortese1 Pedro Romero1 2 Lilia M. lakoucheva3 and Vladimir N. Uversky1 4 1 Department of Biochemistry and Molecular Biology and the Center for ComputationalBiology and Bioinformatics Indiana University Schoolof Medicine Indianapolis IN USA 2 Schoolof Informatics Indiana University - Purdue University Indianapolis IN USA 3 Laboratory of StatisticalGenetics The Rockefeller University New York NY USA 4 Institute for BiologicalInstrumentation Russian Academy of Sciences Moscow Region Russia Correspondence . Dunker Department of Biochemistry and Molecular Biology and the Center for Computational Biology and Bioinformatics Indiana University Schoolof Medicine 714 N Senate Ave Suite 250 Indianapolis IN 46202 USA E-mail kedunker@ Received 25 May 2005 revised 23 August 2005 accepted 30 August 2005 doi Proteins participate in complex sets of interactions that represent the mechanistic foundation for much of the physiology and function of the cell. These protein-protein interactions are organized into exquisitely complex networks. The architecture of protein-protein interaction networks was recently proposed to be scale-free with most of the proteins having only one or two connections but with relatively fewer hubs possessing tens hundreds or more links. The high level of hub connectivity must somehow be reflected in protein structure. What structural quality of hub proteins enables them to interact with large numbers of diverse targets One possibility would be to employ binding regions that have the ability to bind multiple structurally diverse partners. This trait can be imparted by the incorporation of intrinsic disorder in one or both partners. To illustrate the value of such contributions this review examines the roles of intrinsic disorder in protein network architecture. We show that there are three