tailieunhanh - Báo cáo khoa học: cAMP inhibits CSF-1-stimulated tyrosine phosphorylation but augments CSF-1R-mediated macrophage differentiation and ERK activation

Macrophage colony stimulating factor (M-CSF) or CSF-1 controls the development of the macrophage lineage through its receptor tyrosine kin-ase, c-Fms. cAMP has been shown to influence proliferation and differenti-ation in many cell types, including macrophages. In addition, modulation of cellular ERK activity often occurs when cAMP levels are raised. We have shown previously that agents that increase cellular cAMP inhibited CSF-1-dependent proliferation in murine bone marrow-derived macro-phages (BMM) which was associated with an enhanced extracellular signal-regulated kinase (ERK) activity | ềFEBS Journal cAMP inhibits CSF-1-stimulated tyrosine phosphorylation but augments CSF-1R-mediated macrophage differentiation and ERK activation Nicholas J. Wilson1 Maddalena Cross3 Thao Nguyen3 and John A. Hamilton1 2 3 1 Arthritis and Inflammation Research Centre Department of Medicine RMH WH University of Melbourne RoyalMelbourne Hospital Parkville Victoria Australia 2 Department of Medicine RMH WH University of Melbourne RoyalMelbourne Hospital Parkville Victoria Australia 3 CRC for Chronic Inflammatory Diseases Department of Medicine RMH WH University of Melbourne RoyalMelbourne Hospital Parkville Victoria Australia Keywords 8BrcAMP c-Fms MAPK M-CSF prostaglandin Correspondence N. J. Wilson DNAX Research Institute 901 California Ave. Palo Alto CA 94304-1104 USA Fax 1 650 496 1200 Tel 1 650 496 1223 E-mail Present address DNAX Research Institute 901 California Ave Palo Alto CA USA Received 25 April2005 revised 13 June 2005 accepted 20 June 2005 doi Macrophage colony stimulating factor M-CSF or CSF-1 controls the development of the macrophage lineage through its receptor tyrosine kinase c-Fms. cAMP has been shown to influence proliferation and differentiation in many cell types including macrophages. In addition modulation of cellular ERK activity often occurs when cAMP levels are raised. We have shown previously that agents that increase cellular cAMP inhibited CSF-1-dependent proliferation in murine bone marrow-derived macrophages BMM which was associated with an enhanced extracellular signal-regulated kinase ERK activity. We report here that increasing cAMP levels by addition of either 8-bromo cAMP 8BrcAMP or prostaglandin El PGE1 can induce macrophage differentiation in M1 myeloid cells engineered to express the CSF-1 receptor M1 WT cells and can potentiate CSF-1-induced differentiation in the same cells. The enhanced CSF-1-dependent differentiation induced by raising cAMP levels correlated with enhanced

• Báo cáo khoa học
• scientific reports
• Report medicine
• traditional medicine
• Structural biochemistry
• oxidation
• bacteria
• N2 fixation
• Antagonistic effect
• Biological control bacteria pseudomonas
• Inhibits free nitrogen fixing bacteria
• Nitrogen fixing bacteria in the rhizosphere
• Potash mobilizing bacteria
• Rabi sorghum
• Yield of rabi sorghum
• Potash mobilizing bacteria on yield
• Phosphate solubilizing bacteria
• Consortium of azotobacter
• Antibacterial activity of bacteria isolated
• Fermenting cocoa water against
• Pathogenic bacteria
• Selected enteropathogenic bacteria
• Under nails
• Identification of bacteria
• Bacteria from under fingernails
• Identify bacteria contaminants
• IAA producing bacteria
• Indole acetic acid producing bacteria
• Coasts of Ben Tre
• Tra Vinh provinces
• Producing bacteria could naturally stimulate
• Colony bacteria
• Isolation of protease producing bacteria
• Protease producing bacteria
• Soil and characterization
• Characterization of the protease
• Yield parameters
• Phosphate solubilising bacteria
• Potash mobilising bacteria inoculants
• Wheat (Triticum aestivum L
• Inorganic fertilizers on yield of wheat
• Lactic acid bacteria
• Bacteriocin production
• Isolation of probiotic bacteria
• Probiotic bacteria
• Optimization of physical
• Nutrition parameters
• Potassium and phosphorus solubilizing bacteria
• Phosphorus solubilizing bacteria
• Characterization of potassium
• Phosphorus solubilising bacteria
• Employing qualitative plating techniques
• Diazotrophic bacteria
• Influence of diazotrophic bacteria
• Diazotrophic bacteria on growth
• Biomass production
• Sugarcane invitro
• Lactic bacteria
• Physiological parameters
• Food fermented
• Lactic bacteria isolated
• Biodiversity of lactic bacteria isolated
• Lactobacillus sporogenes
• Micrococcus sp
• Histology and intestine
• Lactobacillus sporogenes probiotic bacteria
• Thermophile bacteria
• Growth medium
• Medium growth conditions
• Isolation of thermophilic bacteria
• Thermophilic bacteria
• PhosphateSolubilizing Bacteria (PSB)
• Biochemical characterization
• Rhizosphere soil of rice
• Characterization of phosphate solublizing bacteria
• Phosphate solublizing bacteria
• Lactic acid bacteria and yeast
• Standardization of protocol
• Preparation of linseed beverage
• Cultivable diversity
• Fermented fruit mix
• Characterization of probiotic bacteria
• Isolation of chitinase producing bacteria
• Selection of chitinase producing bacteria
• Antifungal activity against fusarium oxysporum from lilium rhizosphere soil
• Lilium rhizosphere soil
• Chitinase producing bacteria
• Endophytic bacteria
• Bacillus sp
• 16S rRNA sequencing
• Endophytic bacteria from tomato
• Molecular characterization of endophytic bacteria
• Plant Associated Bacteria
• Genomics and recent advances
• The endophytic niche
• Plant growth promoting rhizobacteria
• Their ecology and functions
• Nitrogen fixing bacteria in non legumes
• Water Quality
• Indicator bacteria
• Common sources of E
• coli
• Common routes
• Bacteria to streams
• Risks to human health
• Bacterial diversity
• Sea of Marmara
• Culturable bacteria
• Aerobic heterotrophic bacteria
• Genomic DNAs
• Gram positive bacteria
• Gram negative bacteria
• Lecture AP Biology
• Systems biology
• Biological sciences
• Biological organization
• Isolation of calcite precipitation bacteria
• The strength of concrete
• Materials and methods
• Enrichment of Sample and Bacteria Isolation
• Calcium Carbonate Precipitation and Collection
• Causative bacteria
• Urinary tract infection
• Urinary tract infection in children
• The bacteria was resistant
• The third generation of cephalosporines
• Journal of Automation and Control Engineering
• Development and tuning
• Bacteria foraging optimization algorithm
• Cell formation in cellular manufacturing system
• Cellular manufacturing system
• Bacteria foraging optimization algorithm