tailieunhanh - Báo cáo khoa học: Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation

The abundance and size of cellular organelles vary depending on the cell type and metabolic needs. Peroxisomes constitute a class of cellular organ-elles renowned for their ability to adapt to cellular and environmental conditions. Together with transcriptional regulators, two groups of per-oxisomal proteins have a pronounced influence on peroxisome size and abundance. | FEBS Journal REVIEW ARTICLE Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation Sven Thoms and Ralf Erdmann Ruhr-University-Bochum MedicalFaculty Institute of PhysiologicalChemistry Bochum Germany Keywords dynamin-related protein dynamin endoplasmic reticulum GTPase organelle division peroxisome proliferator-activated receptor peroxisome PEX11 VPS1 yeast Correspondence R. Erdmann Systems Biochemistry Institute of PhysiologicalChemistry Ruhr-University-Bochum 44780 Bochum Germany Fax 49 234321 4266 Tel 49 234322 4943 E-mail The abundance and size of cellular organelles vary depending on the cell type and metabolic needs. Peroxisomes constitute a class of cellular organelles renowned for their ability to adapt to cellular and environmental conditions. Together with transcriptional regulators two groups of peroxisomal proteins have a pronounced influence on peroxisome size and abundance. Pex11-type peroxisome proliferators are involved in the proliferation of peroxisomes defined here as an increase in size and or number of peroxisomes. Dynamin-related proteins have recently been suggested to be required for the scission of peroxisomal membranes. This review surveys the function of Pex11-type peroxisome proliferators and dynamin-related proteins in peroxisomal proliferation and division. Received 28 July 2005 accepted 26 August 2005 doi Introduction Peroxisomes or microbodies are single-membrane bound organelles comprising plant glyoxisomes kineto-plastid glycosomes Woronin bodies and peroxisomes in the narrow sense. Peroxisomes are very diverse in their metabolic functions. Depending on species cell type and environmental conditions peroxisomes may perform different metabolic activities including fatty acid a- and b-oxidation alcohol oxidation ether-lipid biosynthesis glycolysis and glycerol metabolism 1 . In contrast to their metabolic heterogeneity the biogenesis of peroxisomes .