tailieunhanh - Báo cáo khoa học: Two different types of hepcidins from the Japanese flounder Paralichthys olivaceus

The cysteine-rich peptide hepcidin is known to be an antimicrobial peptide and iron transport regulator that has been found in both fish and mam-mals. Recently, we found two different types (designated Hep-JF1 and Hep-JF2) of hepcidin cDNA in the Japanese flounder,Paralichthys oliva-ceus, by expressed sequence tag analysis. The identity of amino acid sequences between Hep-JF1 and Hep-JF2 was 51%. The Hep-JF1 and Hep-JF2 genes both consist of three exons and two introns, and both exist as single copies in the genome. . | ềFEBS Journal Two different types of hepcidins from the Japanese flounder Paralichthys olivaceus Ikuo Hirono Jee-Youn Hwang Yasuhito Ono Tomofumi Kurobe Tsuyoshi Ohira Reiko Nozaki and Takashi Aoki Laboratory of Genome Science Graduate Schoolof Marine Science and Technology Tokyo University of Marine Science and Technology Japan Keywords antimicrobialpeptide gene expression hepcidin Japanese flounder Paralichthys olivaceus Correspondence Takashi Aoki Laboratory of Genome Science Graduate Schoolof Marine Science and Technology Tokyo University of Marine Science and Technology Konan 4-5-7 Minato-ku Tokyo 108-8477 Japan Fax 81 3 54630690 Tel 81 3 54630556 E-mail aoki@ Received 17 May 2005 revised 13 July 2005 accepted 18 August 2005 doi The cysteine-rich peptide hepcidin is known to be an antimicrobial peptide and iron transport regulator that has been found in both fish and mammals. Recently we found two different types designated Hep-JF1 and Hep-JF2 of hepcidin cDNA in the Japanese flounder Paralichthys oliva-ceus by expressed sequence tag analysis. The identity of amino acid sequences between Hep-JF1 and Hep-JF2 was 51 . The Hep-JF1 and Hep-JF2 genes both consist of three exons and two introns and both exist as single copies in the genome. The predicted mature regions of Hep-JF1 and Hep-JF2 have six and eight Cys residues respectively. The first Cys residue of Hep-JF1 was deleted and the second was replaced with Gly. The number and positions of Cys residues in Hep-JF2 are the same as they are in human Hep. Hep-JF1 is specifically expressed in liver while the expression of Hep-JF2 was detected from gill liver heart kidney peripheral blood leucocytes spleen and stomach. Gene expression of Hep-JF1 in liver decreased during experimental iron iron-dextran overload. Expression of Hep-JF1 in liver was decreased by injecting fish with iron-dextran and increased by injecting lipopolysaccharide. Iron overload did not .

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