tailieunhanh - Báo cáo khoa học: Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP/activin pathway

The transforming growth factorb(TGF-b) superfamily includes bone mor-phogenetic proteins, activins and TGF-bsensu stricto (). These ligands, which transduce their signal through a heteromeric complex of type I and type II receptors, have been shown to play a key role in numerous biologi-cal processes including early embryonic development in both deuterostomes and ecdyzozoans. | iFEBS Journal Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP activin pathway Amaury Herpin1 2 Christophe Lelong2 Thomas Becker1 Frederic Rosa3 Pascal Favrel2 and Charles Cunningham1 1 Sars InternationalCentre for Marine Molecular Biology High Technology Centre Bergen Norway 2 Laboratoire de Biologie et Biotechnologies Marines IBFA Universite de Caen Basse-Normandie IFREMER UMR 100 Physiologie et Ecophysiologie des mollusques marins Caen France 3 U 368 INSERM Ecole Normale Superieure Paris France Keywords Crassostrea gigas zebrafish BMP TGF-beta early embyogenesis Correspondence A. Herpin University of Wuerzburg PhysiologicalChemistry I Am Hubland 97074 Wuerzburg Germany Fax 49 931888 4150 Tel 49 931888 4165 E-mail . Received 15 April2005 accepted 12 May 2005 doi The transforming growth factor p TGF-P superfamily includes bone morphogenetic proteins activins and TGF-p sensu stricto . These ligands which transduce their signal through a heteromeric complex of type I and type II receptors have been shown to play a key role in numerous biological processes including early embryonic development in both deuterostomes and ecdyzozoans. Lophochotrozoans the third major group of bilaterian animals have remained in the background of the molecular survey of metazoan development. We report the cloning and functional study of the central part of the BMP pathway machinery in the bivalve mollusc Cras-sostrea gigas Cg-BMPRl type I receptor and Cg-TGFpsfR2 type II receptor showing an unusual functional mode of signal transduction for this superfamily. The use of the zebrafish embryo as a reporter organism revealed that Cg-BMPR1 Cg-TGFpsfR2. Cg-ALR I an activin Type I receptor or their dominant negative acting truncated forms when overexpressed during gastrulation resulted in a

• Báo cáo khoa học
• scientific reports
• Report medicine
• traditional medicine
• biochemical studies
• environmental medicine
• Crystal structure
• BiFeO3 multiferroics
• Magnetic properties
• Bifeo3 polycrystalline ceramics
• Mn CO doping on the crystal structure
• Thermodynamic parameters depend on temperature
• The influence of doping ratio
• The crystal structure metals
• X Ray absorption fine structure
• Hexagonal close packed
• NaZn13 type cubic structure
• Magnetocaloric materials
• The effect of residual la
• Nonlinear optics
• Photonic crystal fiber
• Supercontinuum generation
• scientific research
• Structural biochemistry
• chemical reaction
• tumor cells
• glucanase
• cell signaling
• biochemistry
• Structural Biology
• Klebsiella sp
• immune system
• proteasome deubiquitinating
• medical analysis
• molecular Biology
• genetics
• biological cells
• cytoplasm
• medical knowledge
• BMC Chemistry
• CdO nanoparticles
• Hirschfeld analysis
• Pure cubic nanoparticles
• β Keto enol pyrazole
• Single crystal structure
• NBO analysis
• Reactivity indices
• Fukui and Parr functions
• Biological activity
• X ray crystal structure
• Hirshfeld surface analysis
• Antibacterial and antifungal
• Transition metal complexes
• Bidentate Schiff base ligand
• BMC Bioinformatics
• Atomic displacement parameter
• B factor
• Matthews coefficient
• Protein structure validation
• Journal of Chemistry
• Rietveld refinement
• Titanium oxide
• Microscopy data
• Apatite matrix
• Giant polyoxomolybdates
• Synthesis and crystal structure
• X ray diffraction
• Infrared spectroscopy
• TG analysis
• Monoclinic system
• medical reports
• thesis report