tailieunhanh - Báo cáo khoa học: Fatty acid desaturases from the microalga Thalassiosira pseudonana

Analysis of a draft nuclear genome sequence of the diatomThalassiosira pseudonana revealed the presence of 11 open reading frames showing significant similarity to functionally characterized fatty acid front-end desaturases. The corresponding genes occupy discrete chromosomal loca-tions as determined by comparison with the recently published genome sequence. Phylogenetic analysis showed that two of the T. pseudonana desaturase (Tpdes) sequences grouped with proteobacterial desaturases that lack a fused cytochrome b5 domain. . | ềFEBS Journal Fatty acid desaturases from the microalga Thalassiosira pseudonana Thierry Tonon1 Olga Sayanova2 Louise V. Michaelson2 Renwei Qing1 t David Harvey1 Tony R. Larson1 Yi Li1 Johnathan A. Napier2 and Ian A. Graham1 1 CNAP Department of Biology University of York Heslington York UK 2 Rothamsted Research Institute Harpenden UK Keywords desaturases long chain polyunsaturated fatty acids sphingolipids Thalassiosira pseudonana yeast expression Correspondence I. A. Graham Department of Biology area 7 University of York PO Box373 UK Fax 44 1904 328762 Tel 44 1904 328750 E-mail iag1@ Present addresses UMR 7139 CNRS-GOEMAR-UPMC Station Biologique BP 74 29682 Roscoff cedex France fCollege of Life Science Sichuan University Chengdu China Note The sequences reported in this paper have been submitted to GenBank database under the accession number AY817152 TpdesO AY817153 TpdesA AY817154 TpdesB AY817155 TpdesI and AY817156 TpdesK Received 13 March 2005 revised 22 April 2005 accepted 9 May 2005 doi Analysis of a draft nuclear genome sequence of the diatom Thalassiosira pseudonana revealed the presence of 11 open reading frames showing significant similarity to functionally characterized fatty acid front-end desaturases. The corresponding genes occupy discrete chromosomal locations as determined by comparison with the recently published genome sequence. Phylogenetic analysis showed that two of the T. pseudonana desaturase Tpdes sequences grouped with proteobacterial desaturases that lack a fused cytochrome b5 domain. Among the nine remaining gene sequences temporal expression analysis revealed that seven were expressed in T. pseudonana cells. One of these TpdesN was previously characterized as encoding a A11-desaturase active on palmitic acid. From the six remaining putative desaturase genes we report here that three TpdesI TpdesO and TpdesK respectively encode A6- A5- and A4-desaturases involved in production of the health .

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