tailieunhanh - Báo cáo khoa học: Pharmacology of vascular endothelium Delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw

Sir John Vane named vascular endothelium ‘the maestro of blood circula-tion’. Recently, ‘the maestro’ has become a target for pharmacotherapy of atherothrombotic and diabetic vasculopathies with well known cardio-vascular drugs belonging to the families of Angiotensin Converting Enzyme inhibitors, HMG CoA reductase inhibitors or b1 -Adrenoceptor antagonists. These drugs became upgraded to a position of the pleiotropic endothelial drugs. | THE SIR HANS KREBS LECTURE Pharmacology of vascular endothelium Delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw Ryszard J. Gryglewski Jagiellonian University Cracow Poland Keywords ACE-I ASA bradykinin endothelial dysfunction nitric oxide prostacyclin statins thienopyridines Correspondence R. J. Gryglewski Jagiellonian University Kasztelanska 30 30-116 Cracow Poland E-mail mfgrygle@ Received 10 February 2005 revised 13 April2005 accepted 20 April 2005 doi Sir John Vane named vascular endothelium the maestro of blood circulation . Recently the maestro has become a target for pharmacotherapy of atherothrombotic and diabetic vasculopathies with well known cardiovascular drugs belonging to the families of Angiotensin Converting Enzyme inhibitors HMG CoA reductase inhibitors or bi-Adrenoceptor antagonists. These drugs became upgraded to a position of the pleiotropic endothelial drugs. It is not a simple verbal change in the nomenclature. It means that these drugs apart from their well defined mechanisms of action as indicated in their regular names in addition they act in an unknown mechanism at the level of vascular endothelium preventing angina myocardial infarction and stroke. Many biochemical events take place in endothelial cells. I chose for a closer inspection the nitric oxide prostacyclin defensive system to explain the endothelial pleiotropism of the drugs in question. I tried to examine the validity of this conception according to the general rule in vitro cognitio sed in vivo veritas. Sir Hans Krebs was one of the most versatile biochemists of the twentieth century. Many of his sayings stay as bright as his science. My favourite quotation is . we all are committed to correlating biochemical events to function . the point I want to make is that it is not always immediately clear what their relevance to function may be . 1 . Indeed a burning desire for immediate comprehension amplified by the .