tailieunhanh - Báo cáo khoa học: Biology of mast cell tryptase An inflammatory mediator

In 1960, a trypsin-like activity was found in mast cells [Glenner GG & Cohen LA (1960)Nature185, 846–847] and this activity is now commonly referred to as ‘tryptase’. Over the years, much knowledge about mast cell tryptase has been gathered, and a recent (18 January 2006) PubMed search for the keywords ‘tryptase + mast cell*’ retrieved 1661 articles. | FEBS Journal REVIEW ARTICLE Biology of mast cell tryptase An inflammatory mediator Jenny Hallgren and Gunnar Pejler Department of Molecular Biosciences The BiomedicalCentre Swedish University of AgriculturalSciences Uppsala Sweden Keywords biologicalfunction mast cells regulation tryptase Correspondence G. Pejler Department of Molecular Biosciences The BiomedicalCentre Swedish University of AgriculturalSciences Box 575 751 23 Uppsala Sweden Fax 46 18 550762 Tel 46 18 4714090 E-mail J. Hallgren Brigham and Women s Hospital and Harvard Medical School Smith Research Building One Jimmy Fund Way Boston MA 02115 USA Tel 1 617 525 1290 E-mail jhallgren@ In 1960 a trypsin-like activity was found in mast cells Glenner GG Cohen LA 1960 Nature 185 846-847 and this activity is now commonly referred to as tryptase . Over the years much knowledge about mast cell tryptase has been gathered and a recent 18 January 2006 PubMed search for the keywords tryptase mast cell retrieved 1661 articles. However still very little is known about its true biological function. For example the true physiological substrate s for mast cell tryptase has not been identified and the potential role of tryptase in mast cell-related disease is not understood. Mast cell tryptase has several unique features with perhaps the most remarkable being its organization into a tetrameric state with all of the active sites oriented towards a narrow central pore and its consequent complete resistance towards endogenous macromolecular protease inhibitors. Much effort has been invested to elucidate these properties of tryptase. In this review we summarize the current knowledge of mast cell tryptase including novel insights into its possible biological functions and mechanisms of regulation. Present address Brigham and Women s Hospitaland Harvard Medical School Smith Research Building One Jimmy Fund Way Boston MA 02115 USA Received 23 January 2006 accepted 3 March 2006 doi .

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