tailieunhanh - Báo cáo khoa học: All Other Topics

Current evidence suggests that the beneficial effects of statins seem to be mediated not only by their lipid-lowering properties but also by improving vascular endothelial cell function. Chronic inhibition of endothelial nitric oxide synthesis by oral administration of Nw-nitro-L-arginine methyl ester (L-NAME) to rats induces early vascular inflammation and subsequent arteriosclerosis. | Abstracts All Other Topics F1-1 Effects of atorvastatin on oxidative stress in L-NAME- treated rats R. Gelisgen1 D. Konukoglu1 H. Uzun1 R. Kalayci2 N. Arican3 and M. Kaya4 IDepartment of Biochemistry Cerrahpasa Medical Faculty Istanbul University Istanbul TURKEY 2Istanbul Medical Faculty Research Institute for Experimental Medicine Istanbul University Istanbul TURKEY 3Istanbul Medical Faculty Forensic Medicine Istanbul University Istanbul TURKEY department of Physiology Istanbul Medical Faculty Istanbul University Istanbul TURKEY Current evidence suggests that the beneficial effects of statins seem to be mediated not only by their lipid-lowering properties but also by improving vascular endothelial cell function. Chronic inhibition of endothelial nitric oxide synthesis by oral administration of N w-nitro-L-arginine methyl ester L-NAME to rats induces early vascular inflammation and subsequent arteriosclerosis. To test the relationship between statin atorvastatin therapy and oxidative stress we determine the levels of plasma oxidative stress markers protein carbonyl PCO lipid hydroperoxides LPH and oxidized LDL ox-LDL and plasma antioxidants Paraoxonase -1 PON-1 and total thiol T-SH in L-NAME induced endothelial dysfunction rat models. Adult male Wistar rats were divided into three groups as saline n 8 controls L-NAME 1 mg ml of drinking water for three weeks n 8 and Atorvastatin plus L-NAME 4 mg kg day for 1 week during the third week of L-NAME treatment n 11 . Plasma oxidative marker levels were higher and antioxidative marker levels were lower in L-NAME group than controls for each P . Atorvastatin plus L-NAME group have lower plasma ox-LDL and LPH levels and higher PON-I activities than L-NAME group for each P . Therefore statins are likely to restore the L-NAME-induced inhibition of endothelial NO synthase activity by lowering oxidative stress. F1-2 Circulating oxidized LDL and antibodies against oxidized LDL in type 2 diabetes patients with and .