tailieunhanh - Báo cáo khoa học: Submembraneous microtubule cytoskeleton: biochemical and functional interplay of TRP channels with the cytoskeleton

Much work has focused on the electrophysiological properties of transient receptor potential channels. Recently, a novel aspect of importance emerged: the interplay of transient receptor potential channels with the cytoskeleton. Recent data suggest a direct interaction and functional reper-cussion for both binding partners. | MINIREVIEW Submembraneous microtubule cytoskeleton biochemical and functional interplay of TRP channels with the cytoskeleton Chandan Goswami and Tim Hucho Department for Molecular Human Genetics Max Planck Institute for Molecular Genetics Berlin Germany Keywords actin axonalguidence cytoskeleton growth cone myosin pain signalling complex transient receptor potential channels tubulin varicosity Correspondence C. Goswami Department for Molecular Human Genetics Max Planck Institute for Molecular Genetics Ihnestrasse 73 14195 Berlin Germany Fax 49 30 8413 1383 Tel 49 30 8413 1243 E-mail goswami@ Much work has focused on the electrophysiological properties of transient receptor potential channels. Recently a novel aspect of importance emerged the interplay of transient receptor potential channels with the cytoskeleton. Recent data suggest a direct interaction and functional repercussion for both binding partners. The bi-directionality of physical and functional interaction renders therefore the cytoskeleton a potent integration point of complex biological signalling events from both the cytoplasm and the extracellular space. In this minireview we focus mostly on the interaction of the cytoskeleton with transient receptor potential vanilloid channels. Thereby we point out the functional importance of cytoskeleton components both as modulator and as modulated downstream effector. The resulting implications for patho-biological situations are discussed. Received 15 April 2008 revised 23 June 2008 accepted 30 July 2008 doi The microtubule cytoskeleton plays a role in a variety of cellular aspects such as division morphology and motility as well as the transport of molecules and organelles toward and from the cell membrane. Although all these phenomena affect the plasma membrane however most of the microtubule filaments do not reach to the lipid membrane region partially due to a thick hindering cortical actin network. However .