tailieunhanh - Báo cáo khoa học: Submembraneous microtubule cytoskeleton: regulation of microtubule assembly by heterotrimeric G proteins

Heterotrimeric G proteins participate in signal transduction by transferring signals from cell surface receptors to intracellular effector molecules. G proteins also interact with microtubules and participate in microtubule-dependent centrosome⁄chromosome movement during cell division, as well as neuronal differentiation. | ễFEBS Journal MINIREVIEW Submembraneous microtubule cytoskeleton regulation of microtubule assembly by heterotrimeric G proteins Sukla Roychowdhury1 and Mark M. Rasenick2 1 Neuroscience and Metabolic Disorder Unit Border BiomedicalResearch Center and Department of BiologicalSciences University of Texas ElPaso TX USA 2 Department of Physiology and Biophysics Psychiatry University of Illinois Chicago IL USA Keywords cAMP cytoskeleton G protein-coupled receptor G-protein GTPase microtubules neurite outgrowth RGS synaptic plasticity tubulin Correspondence M. M. Rasenick Department of Physiology and Biophysics University of Illinois at Chicago 835 S. Wolcott m c 901 Chicago IL 60612 USA Fax 1 312 996 1414 Tel 1 312 996 6641 E-mail raz@ S. Roychowdhury Department of Biological Sciences University of Texas at El Paso 500 West University Avenue El Paso TX 79968 USA Fax 1 915 747 5808 Tel 1 915 747 5943 E-mail sukla@ Received 15 April 2008 revised 18 July 2008 accepted 30 July 2008 doi Heterotrimeric G proteins participate in signal transduction by transferring signals from cell surface receptors to intracellular effector molecules. G proteins also interact with microtubules and participate in microtubuledependent centrosome chromosome movement during cell division as well as neuronal differentiation. In recent years significant progress has been made in our understanding of the biochemical functional interactions between G protein subunits a and Py and microtubules and the molecular details emerging from these studies suggest that a and Py subunits of G proteins interact with tubulin microtubules to regulate the assembly dynamics of microtubules providing a novel mechanism for hormone- or neurotransmitter-induced rapid remodeling of cytoskeleton regulation of the mitotic spindle for centrosome chromosome movements in cell division and neuronal differentiation in which structural plasticity mediated by microtubules is .