tailieunhanh - Báo cáo khoa học: Benzo[a]pyrene impairs b-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice A novel molecular mechanism of toxicity for a common food pollutant

Benzo[a]pyrene (B[a]P) is a common food pollutant that causes DNA adduct formation and is carcinogenic. The report of a positive correlation between human plasma B[a]P levels and body mass index, together with B[a]P’s lipophilicity, led us to test for possible adverse effects of B[a]P on adipose tissue. | iFEBS Journal Benzo a pyrene impairs 0-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice A novel molecular mechanism of toxicity for a common food pollutant Philippe Irigaray1 2 Virginie Ogier1 Sandrine Jacquenet1 Veronique Notet1 Pierre Sibille3 Luc Mejean1 2 Bernard E. Bihain1 and Frances T. Yen1 2 1 JE2482 Lipidomix - Institut NationalPolytechnique de Lorraine Vandoeuvre-les-Nancy France 2 Laboratoire de Sciences Animales ENSAIA Vandoeuvre-les-Nancy France 3 Polyclinique de Gentilly Nancy France Keywords adipocytes lipolysis obesity polycyclic aromatic hydrocarbons triglycerides Correspondence . Yen JE2482 Lipidomix Laboratoire de Medecine et Therapeutique Moleculaire 15 rue du Bois de la Champelle 54500 Vandoeuvre-les-Nancy France Fax 33 3 83 67 89 99 Tel 33 3 83 67 89 98 E-mail . Received 26 October 2005 revised 24 January 2006 accepted 31 January 2006 doi Benzo a pyrene B a P is a common food pollutant that causes DNA adduct formation and is carcinogenic. The report of a positive correlation between human plasma B a P levels and body mass index together with B a P s lipophilicity led us to test for possible adverse effects of B a P on adipose tissue. In ex vivo experiments using primary murine adipocytes B a P rapidly within minutes and directly inhibited epinephrine-induced lipolysis up to 75 in a dose-dependent manner. Half-maximum inhibition was obtained with a B a P concentration of mg L-1 pM . Lipolysis induced by P1- p2- and b3-adrenoreceptor-specific agonists as well as ACTH were also significantly inhibited by B a P whereas forskolin-induced lipolysis was not B a P-sensitive. Similar inhibition of catecholamine-induced lipolysis by B a P was also seen in isolated human adipocytes half-maximum inhibition of lipolysis was achieved with a B a P concentration of mg L-1 pM . In vivo treatment of C57Bl 6J mice with mg kg-1 B a P .

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