tailieunhanh - Báo cáo khoa học: Ten years of predictions…and counting

The CASP experiment has been run every other year since 1994. Its objec-tive is to subject the available structure prediction methods to a blind test. This is a short report of the highlights of its last edition. ‘Men who wish to know about the world must learn about it in its partic-ular details’ (Heraclitus of Ephesus, 535–475bc). | FEBS Journal REVIEW ARTICLE Ten years of predictions . and counting Domenico Cozzetto1 Adele Di Matteo1 and Anna Tramontano2 1 Department of BiochemicalSciences University of Rome La Sapienza Italy 2 Istituto Pasteur - Fondazione Cenci Bolognetti University of Rome La Sapienza Italy Keywords automatic prediction servers CASP model evaluation protein structure prediction Correspondence A. Tramontano University of Rome La Sapienza Department of Biochemical Sciences 5 Piazzale Aldo Moro Rome 00185 Italy E-mail The CASP experiment has been run every other year since 1994. Its objective is to subject the available structure prediction methods to a blind test. This is a short report of the highlights of its last edition. Men who wish to know about the world must learn about it in its particular details Heraclitus of Ephesus 535-475 Bc . Received 15 December 2004 accepted 24 December 2004 doi In 2004 the Critical Assessments of Techniques for Protein Structure Prediction CASP celebrates its tenth anniversary. The initiative notwithstanding its relatively long tradition remains lively and challenging. It is organized by John Moult Center for Advanced Research in Biotechnology Rockville MD USA Krzysztof Fidelis Lawrence Livermore National Laboratory Livermore CA USA Tim Hubbard Sanger Institute Hinxton UK Burkhard Rost Columbia University New York NY USA and Anna Tramontano University of Rome Italy with the invaluable help of Andriy Kryshtafovych Lawrence Livermore National Laboratory and Volker Eyrich Columbia University . The goals of the experiments are to evaluate the accuracy of current methods for protein structure prediction to identify bottlenecks and to indicate the directions where efforts can best be focused. The scheme is simple the organizers collect sequences of targets . of proteins the structure of which are likely to be solved within a few weeks. These sequences are made available to the .