tailieunhanh - TOXICITY-PATHWAY-BASED RISK ASSESSMENT PREPARING FOR PARADIGM CHANGE

In 2007, the National Research Council (NRC) released a report titled Toxicity Testing in the 21st Century: A Vision and a Strategy. That report pro- posed a new paradigm for toxicity testing that envisioned evaluation of biologi- cally significant perturbations in key toxicity pathways by using new methods in molecular biology, bioinformatics, and computational toxicology and a compre- hensive array of in vitro tests based primarily on human biology. The revolution in toxicity testing is under way, and a large influx of new data is anticipated. The . Environmental Protection Agency will need to be able to interpret the new data and. | TOXICITY-PATHWAY-BASED RISK ASSESSMENT PREPARING FOR PARADIGM CHANGE A Symposium Summary TOXICITY-PATHWAY-BASED RISK ASSESSMENT PREPARING FOR PARADIGM CHANGE A Symposium Summary Ellen Mantus Rapporteur Standing Committee on Risk Analysis Issues and Reviews Board on Environmental Studies and Toxicology Division on Earth and Life Studies RATIONAL research council OF THE NATIONAL ACADEMIES THE NATIONAL ACADEMIES PRESS Washington . THE NATIONAL ACADEMIES PRESS 500 Fifth Street NW Washington DC 20001 NOTICE The project that is the subject of this report was approved by the Governing Board of the National Research Council whose members are drawn from the councils of the National Academy of Sciences the National Academy of Engineering and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This project was supported by Contract No. EP-C-06-057 between the National Academy of Sciences and the . Environmental Protection Agency. Any opinions findings conclusions or recommendations expressed in this publication are those of the author s and do not necessarily reflect the view of the organizations or agencies that provided support for this project. International Standard Book Number-13 978-0-309-15422-2 International Standard Book Number-10 0-309-15422-7 Additional copies of this report are available from The National Academies Press 500 Fifth Street NW Box 285 Washington DC 20055 800-624-6242 202-334-3313 in the Washington metropolitan area http Copyright 2010 by the National Academy of Sciences. All rights reserved. Printed in the United States of .