tailieunhanh - Báo cáo khoa học: Crustacean hyperglycemic and vitellogenesis-inhibiting hormones in the lobster Homarus gammarus Implications for structural and functional evolution of a neuropeptide family

Crustacean hyperglycemic hormone (CHH) and vitellogenesis-inhibiting hormone (VIH), produced by the X organ–sinus gland neurosecretory com-plex, belong to a peptide group referred to as the CHH family, which is widely distributed in arthropods. In this study, genetic variants and post-translationally modified isoforms of CHH and VIH were characterized in the European lobster Homarus gammarus. | ềFEBS Journal Crustacean hyperglycemic and vitellogenesis-inhibiting hormones in the lobster Homarus gammarus Implications for structural and functional evolution of a neuropeptide family Celine Ollivaux1 Joelle Vinh2 Daniel Soyez1 and Jean-Yves Toullec1 1 Université Pierre et Marie Curie-Paris 6 FRE CNRS 2852 Proteines Biochimie Structurale et Fonctionnelle Equipe Biogenese des Peptides Isomeres Paris France 2 Ecole Superieure de Physique et de Chimie Industrielle de la Ville de Paris UMR CNRS 7637 Laboratoire de Neurobiologie Paris France Keywords aminoacylisomerization crustacean hyperglycemic hormone neuroendocrine cell vitellogenesis-inhibiting hormone X organ-sinus gland Correspondence C. Ollivaux Universite Pierre et Marie Curie-Paris 6 FRE CNRS 2852 Proteines Biochimie Structurale et Fonctionnelle Equipe Biogenese des Peptides Isomeres 7 Quai Saint Bernard 75251 Paris cedex 05 France Fax 33 1 44 27 23 61 Tel 33 1 44 27 22 60 E-mail Database Sequence data for Hog CHH A Hog CHH B and Hog VIH are available in GenBank Database under the accession numbers DQ181791 DQ181792 and DQ181793 respectively. Received 11 January 2006 revised 10 March 2006 accepted 14 March 2006 doi Crustacean hyperglycemic hormone CHH and vitellogenesis-inhibiting hormone VIH produced by the X organ-sinus gland neurosecretory complex belong to a peptide group referred to as the CHH family which is widely distributed in arthropods. In this study genetic variants and post-translationally modified isoforms of CHH and VIH were characterized in the European lobster Homarus gammarus. With the use of RP-HPLC and ELISA with specific antibodies that discriminate between stereoisomers of CHH and VIH two groups of CHH-immunoreactive peaks were characterized from HPLC fractions of sinus gland extract CHH A and CHH B each group contained two variants CHH and D-Phe3CHH . In the same way two VIH-immunoreactive peaks VIH and D-Trp4VIH were .

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