tailieunhanh - EVOLUTION OF THE MOLECULAR BIOLOGY OF BRAIN TUMORS AND THE THERAPEUTIC IMPLICATIONS

Although technical advances have resulted in marked improvements in the ability to diag‐ nose and surgically treat primary and metastatic brain tumors, the incidence and mortality rates of these tumors is increasing. Particularly affected are young adults and the elderly. The present standard treatment modalities following surgical resection including cranial irradia‐ tion and systemic or local chemotherapy each have limited efficacy and serious adverse side effects. Furthermore the relatively few long-term survivors are inevitably left with cognitive deficits and other disabilities. The difficulties in treating malignant gliomas can be attributed to several factors. Glial tumors. | EVOLUTION OF THE MOLECULAR BIOLOGY OF BRAIN TUMORS AND THE THERAPEUTIC IMPLICATIONS Edited by Terry Lichtor Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications http 50198 Edited by Terry Lichtor Contributors Bruno Costa Chunzhi Zhang Martin Jadus Satoshi Utsuki Almos Klekner Hassan Mahmoud Fathallah-Shaykh Elza Tiemi Sakamoto-Hojo Geraldo Passos Paulo Roberto D Auria Vieira Godoy Flavia Donaires Patricia Carminati Ana Paula Montaldi Jarah Meador Adayabalam Balajee Mine Erguven Phanithi Prakash Babu Giuseppe Raudino Mariella Caffo Gerardo Caruso Concetta Alafaci Federica Raudino Valentina Marventano Alberto Romano Francesco Montemagno Massimo Belvedere Francesco Maria Salpietro Francesco Tomasello Anna Schillaci Wenbo Zhu Guangmei Yan Sihan Wu Stephano Spano Mello Eduardo Donadi James Rutka ANDRES CARDONA LEON DARIO ORTIZ Toshiyuki Ishiwata Yoko Matsuda Hisashi Yoshimura Petr Busek Aleksi Sedo Davide Schiffer Lee Roy Morgan Joonas Haapasalo Kristiina Nordfors Hannu Haapasalo Seppo Parkkila Albert Magro Nic Savaskan Valeria Barresi Francesca Granata Mario Venza Jerzy Trojan Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2013 InTech All chapters are Open Access distributed under the Creative Commons Attribution license which allows users to download copy and build upon published articles even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No .