tailieunhanh - Báo cáo khoa học: Cross-talk between the bone morphogenetic protein pathway and other major signaling pathways results in tightly regulated cell-specific outcomes

Members of the bone morphogenetic protein (BMP) family of ligands have been identified in a variety of vertebrate and invertebrate species and have been shown to play an essential role in a range of biological processes, including mesodermal patterning and organ development, as well as the formation of bone and cartilage. | ỊFEBS Journal MINIREVIEW Cross-talk between the bone morphogenetic protein pathway and other major signaling pathways results in tightly regulated cell-specific outcomes Amaury Herpin1 and Charles Cunningham2 1 Department of PhysiologicalChemistry I University of Wuerzburg Germany 2 Department of Biology University of New Mexico Albuquerque NM USA Keywords activin BMP cross-talk MAP kinase notch TGF-P Toll Correspondence A. Herpin PhysiologicalChemistry I University of Wuerzburg Am Hubland D-97074 Wuerzburg Germany Fax 49 931 888 4150 Tel 49 931 888 4156 E-mail . Received 29 November 2006 revised 6 February 2007 accepted 15 March 2007 doi Members of the bone morphogenetic protein BMP family of ligands have been identified in a variety of vertebrate and invertebrate species and have been shown to play an essential role in a range of biological processes including mesodermal patterning and organ development as well as the formation of bone and cartilage. Although the interaction of BMP ligands with specific type I and II serine-threonine kinase receptor complexes is crucial to the initiation of signaling it is the interaction of intracellular signaling molecules called Smads with receptor complexes and other transcription factors that defines the repertoire of biological responses associated with the BMPs. But although all BMP ligands appear to interact with specific type I and II receptors growing biochemical and developmental evidence supports the notion that alternative non-Smad pathways also participates in BMP signaling. Here we review the interaction or cross-talk between the BMP and other major signaling pathways transforming growth factor P activin Notch p38 mitogen-activated protein kinase and Toll that results in tightly regulated cell-specific outcomes. Introduction The transforming growth factor P TGF-P superfamily includes numerous growth factors which share highly conserved common