tailieunhanh - Rhinitis/Polyposis/Sinusitis - 2008 AAAAI/ACAAI Joint Board Review Course

o The adaptive immune system becomes activated in specific stimulus. Specific antigens are presented to T lymphocytes (cytotoxic T cells, as well as T helper cells) by antigen-presenting cells, such as monocytes, macrophages, B-lymphocytes, and dendritic cells. In the peripheral blood, two major subtypes of dendritic cells are identified, myeloid dendritic cells (MDC), and plasmacytoid dendritic cells (PDC) (182) . Hartmann et al. demonstrated the presence of PDC and MDC in the healthy nasal epithelium and in nasal epithelia from patients with different pathological conditions (183) . Antigen-presenting cells need to process the complex protein antigens into ‘minimal antigenic peptides’, which are. | Disclosures Commercial interests None Stocks None. Consulting Advisory Board Sinexus Genentech ISIS Dey LP Schering-Plough Novartis Accentia Speaker or Honorarium Merck Genentech Novartis Critical Therapeutics Research Grant Flight Attendants Medical Research Institute FAMRI Merck AR prevalence and epidemiology Adults 0 prevalence based on NHANES II based on skin testing 15-18 of white population 0 higher rates in African-Americans and Latino populations Children E prevalence appears to be increasing 0 prevalence of AR 3x greater than that of asthma The vast majority of patients with asthma have rhinitis. Togias A JACI 111 1171 .