tailieunhanh - Báo cáo khoa học: Endothelial signalling events during leukocyte transmigration

The notion that it takes two to tango is certainly true for leukocyte trans-endothelial migration. A growing pallet of leukocyte adhesion-induced signaling events in endothelial cells have been identified, mediating both short-term (. permeability) as well as long-term (. regulation of tran-scription) effects. | MINIREVIEW Endothelial signalling events during leukocyte transmigration Peter L. Hordijk Department of Molecular Cell Biology Sanquin Research and Landsteiner Laboratory Academic MedicalCenter University of Amsterdam the Netherlands Keywords adhesion ICAM-1 migration transendothelialmigration VCAM-1 Correspondence P. L. Hordijk Department of Molecular Cell Biology Sanquin Research and Landsteiner Laboratory Academic Medical Center University of Amsterdam Plesmanlaan 125 1066 CX Amsterdam the Netherlands Fax 31 20 5123474 Tel 31 20 5123263 E-mail The notion that it takes two to tango is certainly true for leukocyte trans-endothelial migration. A growing pallet of leukocyte adhesion-induced signaling events in endothelial cells have been identified mediating both short-term . permeability as well as long-term . regulation of transcription effects. Efficient paracellular migration . through endothelial cell-cell junctions requires both intracellular calcium and the actin cytoskeleton but also involves small GTPases reactive oxygen species and protein kinases. The alternative route of transcellular migration appears to depend on components such as caveolae and intermediate filaments. This minireview discusses our current knowledge on the regulation of leukocyte transmigration through endothelial signalling. Received 15 May 2006 accepted 17 July 2006 doi Transendothelial migration TEM is an essential aspect of the trafficking of leukocytes as well as of malignant cells. Much pathology is associated with uncontrolled TEM for instance in chronic inflammatory disorders asthma rheumatoid arthritis psoriasis and in metastasis. On the other hand regulated leukocyte trafficking is required for immune surveillance and stem cell homing following transplantation procedures. The multistep model for TEM 1 is well established and probably applies to most transmigration events albeit that tissue specificity may result in