tailieunhanh - Báo cáo khoa học: Worth the effort An account of the Seventh Meeting of the Worldwide Critical Assessment of Techniques for Protein Structure Prediction

A chilly, but still very attractive, Asilomar hosted the seventh edition of the Critical Assessment of Protein Structure Prediction Experiment (CASP) [1]. A few months ago, 96 protein sequences of unknown, but soon to be determined structure, were distributed to more than 250 groups, whose task was to predict their structure and a number of other fea-tures, such as their domain boundaries, the presence of disordered regions, contacts between specific amino acids and their molecular function. | IFEBS Journal REVIEW ARTICLE Worth the effort An account of the Seventh Meeting of the Worldwide Critical Assessment of Techniques for Protein Structure Prediction Anna Tramontane1 2 1 Department of BiochemicalSciences University of Rome La Sapienza Italy 2 Istituto Pasteur Fondazione Cenci Bolognetti Rome Italy Correspondence A. Tramontano Department of Biochemical Sciences Rossi Fanelli University of Rome La Sapienza Aldo Moro 5 00185 Rome Italy Fax 39 06 4440062 or 39 06 4453933 Tel 39 06 49910556 E-mail Received 4 December 2006 revised 24 January 2007 accepted 29 January 2007 doi A chilly but still very attractive Asilomar hosted the seventh edition of the Critical Assessment of Protein Structure Prediction Experiment CASP 1 . A few months ago 96 protein sequences of unknown but soon to be determined structure were distributed to more than 250 groups whose task was to predict their structure and a number of other features such as their domain boundaries the presence of disordered regions contacts between specific amino acids and their molecular function. As soon as the structure of a target protein was available the prediction centre at UC Davis http compared it with all submitted predictions computed several parameters and passed them to a set of experts who were given the task to draw conclusions about the state of the art in the field. This year the assessors for structure prediction were Neil Clarke Genome Institute of Singapore Singapore Torsten Schwede Swiss Institute of Bioinformatics Basel Switzerland and Randy Read Cambridge Institute for Medical Research Cambridge UK . Alfonso Valencia Spanish National Cancer Research Centre Madrid Spain Lorenza Bortoli Swiss Institute of Bioinformatics Neil Clarke and Mike Tress Spanish National Cancer Research Centre Madrid Spain assessed the so-called other categories namely function prediction disordered regions contacts and

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