tailieunhanh - Báo cáo khoa học: Weapons of STAT destruction Interferon evasion by paramyxovirus V proteins

The signal transducer and activator of transcription (STAT) family of proteins function to activate gene transcription downstream of myriad cytokine and growth factor signals. The prototype STAT proteins, STAT1 and STAT2, are required for innate and adaptive antimicrobial immune responses that result from interferon signal transduction. While many viruses have evolved the ability to avoid these antiviral cytokines, the Paramyxoviruses are distinct in their abilities to interfere directly with STAT proteins. . | Eur. J. Biochem. 271 4621-4628 2004 FEBS 2004 doi MINIREVIEW Weapons of STAT destruction Interferon evasion by paramyxovirus V proteins Curt M. Horvath Department of Medicine Evanston Northwestern Healthcare Research Institute and Departments of Medicine and Biochemistry Molecular Biology Cell Biology Northwestern University Evanston IL USA The signal transducer and activator of transcription STAT family of proteins function to activate gene transcription downstream of myriad cytokine and growth factor signals. The prototype STAT proteins STAT1 and STAT2 are required for innate and adaptive antimicrobial immune responses that result from interferon signal transduction. While many viruses have evolved the ability to avoid these antiviral cytokines the Paramyxoviruses are distinct in their abilities to interfere directly with STAT proteins. Individual paramyxovirus species differ greatly in their precise mechanism of STAT signaling evasion but a virus-encoded pro tein called V plays a central role in this process. The theme of V-dependent interferon evasion and its variations provide significant insights into virus-host interactions and viral immune evasion that can help define targets for antiviral drug design. Exposure of the viral weapons of STAT destruction may also be instructive for application to STAT-directed therapeutics for diseases characterized by STAT hyperactivity. Keywords antiviral interferon paramyxovirus STAT viral evasion. Interferons the antiviral cytokines The interferon IFN family including type I IFNa IFNb and type II IFNy refers to a group of cytokines that are capable of modulating diverse biological responses such as immune regulation tumor inhibition cell growth arrest innate antimicrobial responses and promotion of adaptive immunity. Type I IFNs have long been associated with the ability to diminish virus replication 1 and this antiviral activity is the result of IFN-induced changes in cellular gene .

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