tailieunhanh - Báo cáo khoa học: Sialylation of urinary prothrombin fragment 1 is implicated as a contributory factor in the risk of calcium oxalate kidney stone formation

Urinary glycoproteins are important inhibitors of calcium oxalate crystal-lization and adhesion of crystals to renal cells, both of which are key mech-anisms in kidney stone formation. This has been attributed to glycosylation of the proteins. In South Africa, the black population rarely form stones (incidence | iFEBS Journal Sialylation of urinary prothrombin fragment 1 is implicated as a contributory factor in the risk of calcium oxalate kidney stone formation Dawn Webber1 Catherine M. Radcliffe2 Louise Royle2 Gemma Tobiasen2 Anthony H. Merry2 Allen L. Rodgers1 Edward D. Sturrock3 Mark R. Wormald2 David J. Harvey2 Raymond A. Dwek2 and Pauline M. Rudd2 1 Department of Chemistry University of Cape Town South Africa 2 Department of Biochemistry Glycobiology Institute University of Oxford UK 3 Division of MedicalBiochemistry and Institute of Infectious Disease and Molecular Medicine University of Cape Town South Africa Keywords calcium oxalate glycosylation kidney stones sialic acid urinary prothrombin fragment 1 Correspondence P. M. Rudd Glycobiology Institute Department of Biochemistry South Parks Road University of Oxford Oxford OX1 3QU UK Fax 44 1865 275796 Tel 44 1865 275340 E-mail Received 2 February 2006 revised 5 April 2006 accepted 10 May 2006 doi Urinary glycoproteins are important inhibitors of calcium oxalate crystallization and adhesion of crystals to renal cells both of which are key mechanisms in kidney stone formation. This has been attributed to glycosylation of the proteins. In South Africa the black population rarely form stones incidence 1 compared with the white population incidence 12-15 . A previous study involving urinary prothrombin fragment 1 from both populations demonstrated superior inhibitory activity associated with the protein from the black group. In the present study we compared N-linked and O-linked oligosaccharides released from urinary prothrombin fragment 1 isolated from the urine of healthy and stone-forming subjects in both populations to elucidate the relationship between glycosylation and calcium oxalate stone pathogenesis. The O-glycans of both control groups and the N-glycans of the black control samples were significantly more sialylated than those of the white .

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