tailieunhanh - Báo cáo khoa học: Mechanisms of amyloid fibril self-assembly and inhibition Model short peptides as a key research tool

The formation of amyloid fibrils is associated with various human medical disorders of unrelated origin. Recent research indicates that self-assembled amyloid fibrils are also involved in physiological processes in several micro-organisms. Yet, the molecular basis for the recognition and self-assembly processes mediating the formation of such structures from their soluble protein precursors is not fully understood. | ềFEBS Journal MINIREVIEW Mechanisms of amyloid fibril self-assembly and inhibition Model short peptides as a key research tool Ehud Gazit Department of Molecular Microbiology and Biotechnology TelAviv University TelAviv Israel Keywords amyloid formation molecular recognition protein folding protein misfolding proteinprotein interactions self-assembly stacking interactions Correspondence E. Gazit Department of Molecular Microbiology and Biotechnology TelAviv University TelAviv 69978 Israel Fax 972 3 640 5448 Tel 972 3 640 9030 E-mail ehudg@ Received 2 June 2005 accepted 10 October 2005 doi The formation of amyloid fibrils is associated with various human medical disorders of unrelated origin. Recent research indicates that self-assembled amyloid fibrils are also involved in physiological processes in several microorganisms. Yet the molecular basis for the recognition and self-assembly processes mediating the formation of such structures from their soluble protein precursors is not fully understood. Short peptide models have provided novel insight into the mechanistic issues of amyloid formation revealing that very short peptides as short as a tetrapeptide contain all the necessary molecular information for forming typical amyloid fibrils. A careful analysis of short peptides has not only facilitated the identification of molecular recognition modules that promote the interaction and selfassembly of fibrils but also revealed that aromatic interactions are important in many cases of amyloid formation. The realization of the role of aromatic moieties in fibril formation is currently being used to develop novel inhibitors that can serve as therapeutic agents to treat amyloid-associated disorders. The formation of well-ordered amyloid fibrils by the self-assembly of various proteins and polypeptides is associated with serious human medical disorders like Alzheimer s disease prion disorders bovine spongiform encephalopathy .

• Báo cáo khoa học
• Report medicine
• traditional medicine
• scientific reports
• Structural biochemistry
• oxidation
• bacteria
• N2 fixation
• Antagonistic effect
• Biological control bacteria pseudomonas
• Inhibits free nitrogen fixing bacteria
• Nitrogen fixing bacteria in the rhizosphere
• Potash mobilizing bacteria
• Rabi sorghum
• Yield of rabi sorghum
• Potash mobilizing bacteria on yield
• Phosphate solubilizing bacteria
• Consortium of azotobacter
• Antibacterial activity of bacteria isolated
• Fermenting cocoa water against
• Pathogenic bacteria
• Selected enteropathogenic bacteria
• Under nails
• Identification of bacteria
• Bacteria from under fingernails
• Identify bacteria contaminants
• IAA producing bacteria
• Indole acetic acid producing bacteria
• Coasts of Ben Tre
• Tra Vinh provinces
• Producing bacteria could naturally stimulate
• Colony bacteria
• Isolation of protease producing bacteria
• Protease producing bacteria
• Soil and characterization
• Characterization of the protease
• Yield parameters
• Phosphate solubilising bacteria
• Potash mobilising bacteria inoculants
• Wheat (Triticum aestivum L
• Inorganic fertilizers on yield of wheat
• Lactic acid bacteria
• Bacteriocin production
• Isolation of probiotic bacteria
• Probiotic bacteria
• Optimization of physical
• Nutrition parameters
• Potassium and phosphorus solubilizing bacteria
• Phosphorus solubilizing bacteria
• Characterization of potassium
• Phosphorus solubilising bacteria
• Employing qualitative plating techniques
• Diazotrophic bacteria
• Influence of diazotrophic bacteria
• Diazotrophic bacteria on growth
• Biomass production
• Sugarcane invitro
• Lactic bacteria
• Physiological parameters
• Food fermented
• Lactic bacteria isolated
• Biodiversity of lactic bacteria isolated
• Lactobacillus sporogenes
• Micrococcus sp
• Histology and intestine
• Lactobacillus sporogenes probiotic bacteria
• Thermophile bacteria
• Growth medium
• Medium growth conditions
• Isolation of thermophilic bacteria
• Thermophilic bacteria
• PhosphateSolubilizing Bacteria (PSB)
• Biochemical characterization
• Rhizosphere soil of rice
• Characterization of phosphate solublizing bacteria
• Phosphate solublizing bacteria
• Lactic acid bacteria and yeast
• Standardization of protocol
• Preparation of linseed beverage
• Cultivable diversity
• Fermented fruit mix
• Characterization of probiotic bacteria
• Isolation of chitinase producing bacteria
• Selection of chitinase producing bacteria
• Antifungal activity against fusarium oxysporum from lilium rhizosphere soil
• Lilium rhizosphere soil
• Chitinase producing bacteria
• Endophytic bacteria
• Bacillus sp
• 16S rRNA sequencing
• Endophytic bacteria from tomato
• Molecular characterization of endophytic bacteria
• Plant Associated Bacteria
• Genomics and recent advances
• The endophytic niche
• Plant growth promoting rhizobacteria
• Their ecology and functions
• Nitrogen fixing bacteria in non legumes
• Water Quality
• Indicator bacteria
• Common sources of E
• coli
• Common routes
• Bacteria to streams
• Risks to human health
• Bacterial diversity
• Sea of Marmara
• Culturable bacteria
• Aerobic heterotrophic bacteria
• Genomic DNAs
• Gram positive bacteria
• Gram negative bacteria
• Lecture AP Biology
• Systems biology
• Biological sciences
• Biological organization
• Isolation of calcite precipitation bacteria
• The strength of concrete
• Materials and methods
• Enrichment of Sample and Bacteria Isolation
• Calcium Carbonate Precipitation and Collection
• Causative bacteria
• Urinary tract infection
• Urinary tract infection in children
• The bacteria was resistant
• The third generation of cephalosporines
• Journal of Automation and Control Engineering
• Development and tuning
• Bacteria foraging optimization algorithm
• Cell formation in cellular manufacturing system
• Cellular manufacturing system
• Bacteria foraging optimization algorithm