tailieunhanh - Báo cáo khoa học: From functional genomics to systems biology Meeting report based on the presentations at the 3rd EMBL Biennial Symposium 2006 (Heidelberg, Germany) Sergii Ivakhno

This review discusses the talks presented at the third EMBL Biennial Sym-posium, From functional genomics to systems biology, held in Heidelberg, Germany, 14–17 October 2006. Current issues and trends in various sub-fields of functional genomics and systems biology are considered, including analysis of regulatory elements, signalling networks, transcription networks, protein–protein interaction networks, genetic interaction networks, medical applications of DNA microarrays, and metagenomics. | IFEBS Journal REVIEW ARTICLE From functional genomics to systems biology Meeting report based on the presentations at the 3rd EMBL Biennial Symposium 2006 Heidelberg Germany Sergii Ivakhno Institute for Adaptive and NeuralComputation Schoolof Informatics University of Edinburgh UK Keywords DNA microarray medical applications functional genomics genetic interaction networks networks biology signalling networks systems biology Correspondence S. Ivakhno Institute for Adaptive and Neural Computation Schoolof Informatics University of Edinburgh E4 5 Forrest Hill Edinburgh EH1 2QL UK Fax 44 0 131 6506899 Tel 44 0 131 6676000 ext. 0131 6684266 E-mail s0567096@ This review discusses the talks presented at the third EMBL Biennial Symposium From functional genomics to systems biology held in Heidelberg Germany 14-17 October 2006. Current issues and trends in various subfields of functional genomics and systems biology are considered including analysis of regulatory elements signalling networks transcription networks protein-protein interaction networks genetic interaction networks medical applications of DNA microarrays and metagenomics. Several technological advances in the fields of DNA microarrays identification of regulatory elements in the genomes of higher eukaryotes and MS for detection of protein interactions are introduced. Major directions of future systems biology research are also discussed. Received 30 January 2007 revised 1 March 2007 accepted 12 March 2007 doi Introduction The third EMBL Biennial Symposium From functional genomics to systems biology was held in Heidelberg Germany 14-17 October 2006. The title of the conference clearly states the major challenges and issues that were addressed by the speakers - how to combine different omics technologies and bioinfor-matics computational methodologies to address increasingly complex biological questions. The main conference was divided into five separate sessions .