tailieunhanh - THE PROTEIN DISEASE DATABASE OF HUMAN BODY FLUIDS

Endocrine disruptors function by: (i) Mimicking the action of a naturally-produced hormone, such as estrogen or testosterone, thereby setting off similar chemical reactions in the body; (ii) Blocking hormone receptors in cells, thereby preventing the action of normal hormones; or (iii) Affecting the synthesis, transport, metabolism and excretion of hormones, thus altering the concentrations of natural hormones. Endocrine disruptors have been linked to attention deficit hyperactivity disorder (ADHD), Parkinson’s and Alzheimer’s diseases, diabetes, cardiovascular disease, obesity, early puberty, infertility and other reproductive disorders, and childhood and adult cancers. More than 50 pesticide active ingredients have been identified as endocrine disruptors by. | Applied and Theoretical Electrophoresis 1995 5 55-72 Electrophoresis Society 1995 The Protein Disease Database of human body fluids II. Computer methods and data issues Peter F. Lemkin1 Geoffrey A. Orr2 Mark p. Goldstein3 G. Joseph Creed4 James E. Myrick5 Carl R. Merril4 1 Image Processing Section LMMB Building 469 Room Ỉ5Q NCFFCRDC NIH Frederick MD 21702 2PRI Dyncorp NCI-FCRDC Frederick MD 3Monoclonetics Int l. Houston TX LBG NIMH NIH Neuroscience Center Washington . SNCEH CDCP Div. Environ. Health Lab. Sen Atlanta GA The Protein Disease Database PDD is a relational database of proteins and diseases. With this database it is possible to screen for quantitative protein abnormalities associated with disease states. These quantitative relationships use data drawn from the peer-reviewed biomedical literature. Assays may also include those observed in high-resolution electrophoretic gels that offer the potential to quantitate many proteins in a single test as well as data gathered by enzymatic or immunologic assays. We are using the Internet World Wide Web WWW and the Web browser paradigm as an access method for wide distribution and querying of the Protein Disease Database. The WWW hypertext transfer protocol and its Common Gateway Interface make it possible to build powerful graphical user interfaces that can support easy-to-use data retrieval using query specification forms or images. The details of these interactions are totally transparent to the users of these forms. Using a client-server SQL relational database user query access initial data entry and database maintenance are all performed over the Internet with a Web browser. We discuss the underlying design issues mapping mechanisms and assumptions that we used in constructing the system data entry access to the database server security and synthesis of derived two-dimensional gel image maps and hypertext documents resulting from SQL database searches. Keywords Protein Disease Database PDD World-Wide-Web .