tailieunhanh - Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor

Growth factors are a group of proteins that regulate a wide variety of cel-lular processes, including proliferation, differentiation, motility, adhesion, and apoptosis of target cells. They play crucial roles in the formation and maintenance of tissue architecture in embryonic development and adult tissue homeostasis. | MINIREVIEW Hepatocyte growth factor activator HGFA a serine protease that links tissue injury to activation of hepatocyte growth factor Keiji Miyazawa Department of Biochemistry Interdisciplinary Graduate Schoolof Medicine and Engineering University of Yamanashi Japan Keywords hepatocyte growth factor plasminogen proteolytic activation tissue injury Correspondence K. Miyazawa Department of Biochemistry Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi 1110 Shimokato Chuo Yamanashi 409-3898 Japan Fax Tel 81 55 273 6784 E-mail keiji-miyazawa@ Received 26 November 2009 revised 3 February 2010 accepted 26 February 2010 doi Growth factors are a group of proteins that regulate a wide variety of cellular processes including proliferation differentiation motility adhesion and apoptosis of target cells. They play crucial roles in the formation and maintenance of tissue architecture in embryonic development and adult tissue homeostasis. Because aberrations in growth factor signaling often result in pathological conditions the activities of growth factors are tightly controlled by extracellular and intracellular regulators. Hepatocyte growth factor HGF is a mesenchymal cell-derived growth factor that affects various target cells including epithelial and endothelial cells. HGF is synthesized and secreted as a latent form and is proteolytically activated in response to tissue injury thus participating in tissue regeneration and repair. Interestingly HGF has a unique structural feature it is homologous to plasminogen a key enzyme in the fibrinolytic system. Elucidation of the regulatory mechanisms of HGF activity has revealed that a blood coagulation factor XII-like serine protease hepatocyte growth factor activator efficiently converts HGF from the latent form to the active form. Hepatocyte growth factor activator itself is activated downstream of the blood coagulation cascade and links tissue injury