tailieunhanh - CARDIAC DRUG THERAPY - PART 3

Với isradipine và felodipin, tương tác xảy ra với cimetidine, các thuốc chống động kinh, và nước bưởi. Felodipine (Plendil) là chất đối kháng canxi được sử dụng trong điều trị cao huyết áp tối ưu (HOT) nghiên cứu (27). | 74 Cardiac Drug Therapy Drug name Felodipine Trade names Plendil Renedil Supplied 5 10 mg Dosage Hypertension mg once daily max. 10 mg reduce dosage in the elderly and in hepatic impairment With isradipine and felodipine interactions occur with cimetidine antiepileptic agents and grapefruit juice. Felodipine Plendil was the calcium antagonist used in the Hypertension Optimal Treatment HOT study 27 . The drug proved remarkably safe and in combination with other agents was effective in decreasing diastolic pressures to the desired goal it resulted in a significant reduction of fatal and nonfatal strokes. Drug name Nicardipine Trade name Cardene Dosage 5-30 mg twice daily Nicardipine has actions effects and indications similar to those of nifedipine. Drug name Nimodipine Trade name Nimotop Dosage mg kg four times hourly see text for further advice Nimodipine is useful in the management of cerebral arterial spasm after subarachnoid hemorrhage 28 . Dosage Further Advice For patients over 70 kg use an IV central line 1 mg h initially increasing after 2 h to 2 mg h if hypotension does not occur. Halve the dose in patients weighing less than 70 kg. Use the IV route for 5 d and then give orally 60 mg every 4 h starting within 4 d of subarachnoid hemorrhage and for 21 d. Drug name Nisoldipine Trade names Sular Syscor UK Dosage 10 mg daily max. 40 mg Nisoldipine has been observed to cause enhanced platelet aggregation as well as exacerbation of myocardial ischemia on abrupt withdrawal. Other DHPs include azodipine diazodipine flordipine iodipine and lacidipine Motens UK the dose is 2-4 mg daily maximum 6 mg once daily. Also available are mesudipine niludipine nilvadipine nitrendipine oxodipine riodipine ryosidine and vadipine. What has been described in the earlier discussion of actions advice and adverse effects for nifedipine should apply to the aforementioned drugs except for their duration of action. Mibefradil Posicor a T channel blocker has caused severe