tailieunhanh - Báo cáo y học: " Psychiatric disorder in early adulthood and risk of premature mortality in the 1946 British Birth Cohort"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Psychiatric disorder in early adulthood and risk of premature mortality in the 1946 British Birth Cohort | Henderson et al. BMC Psychiatry 2011 11 37 http 1471-244X 11 37 BMC Psychiatry RESEARCH ARTICLE Open Access Psychiatric disorder in early adulthood and risk of premature mortality in the 1946 British Birth Cohort 1 2 3 2 3 Max Henderson Matthew Hotopf Imran Shah Richard D Hayes Diana Kuh Abstract Background Few studies of the association between psychiatric disorder and premature death have adjusted for key confounders and used structured psychiatric interviews. We aimed to investigate if psychiatric disorder was associated with a higher risk of mortality and whether any excess mortality was due to suicide or explained by other health or socioeconomic risk factors. Methods We used data from the MRC National Survey of Health and Development a nationally representative UK birth cohort. 3283 men and women completed the Present State Examination at age 36. The main outcome measure was all-cause mortality before age 60. Results Those with psychiatric disorder at age 36 had a higher risk of death even after adjusting for potential confounders Hazard ratio 95 . . Censoring violent deaths and suicides led to similar results. Conclusions Psychiatric disorder was associated with excess premature mortality not explained by suicide or other health or socioeconomic risk factors. Background Many studies have shown an association between psychiatric disorder and premature death 1-5 mainly from cardiovascular disease 6-9 and suicide 9-11 . However negative findings 12 13 have been reported and questions regarding the degree to which any association may be accounted for by confounding or mediating factors remain unresolved 8 . Existing studies have significant limitations. Few are population-based 8 follow-up periods are often short 14 15 many have relied on subjective measures of psychiatric disorder 16-18 and almost none have controlled for key potential mediating factors including physical health status at baseline tobacco and alcohol .

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