tailieunhanh - Báo cáo y học: " Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II | BioMed Central BMC Psychiatry Open Access Study protocol Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses Health Study II Karestan C Koenen 1 3 Immaculata De Vivo2 3 Janet Rich-Edwards2 3 Jordan W Smoller4 Rosalind J Wright1 3 and Shaun M Purcell4 5 Address Department of Society Human Development and Health Harvard School of Public Health Boston MA 02115 USA 2Department of Epidemiology Harvard School of Public Health Boston MA 02115 3Channing Laboratory Brigham and Women s Hospital Boston MA 02115 USA 4Department of Psychiatry Psychiatric and Neurodevelopment Genetics Unit Center for Genetic Research Massachusetts General Hospital and Harvard Medical School Boston MA 02114 USA and 5The Broad Institute Cambridge MA 02141 USA Email Karestan C Koenen - kkoenen@ Immaculata De Vivo - devivo@ Janet Rich- Edwards - jr33@ Jordan W Smoller - jordan_smoller@ Rosalind J Wright - Shaun M Purcell - shaun@ Corresponding author Published 29 May 2009 Received 17 April 2009 BMC Psychiatry 2009 9 29 doi 1471-244X-9-29 Accepted 29 May 2009 This article is available from http 1471-244X 9 29 2009 Koenen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background One in nine American women will meet criteria for the diagnosis of posttraumatic stress disorder PTSD in their lifetime. Although twin studies suggest genetic influences account for substantial variance in PTSD risk little progress has been made in identifying variants in specific genes that influence liability to this common debilitating disorder. Methods and design We