tailieunhanh - Báo cáo y học: " Reduced antioxidant defense in early onset first-episode psychosis: a case-control study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Reduced antioxidant defense in early onset first-episode psychosis: a case-control study | Micó et al. BMC Psychiatry 2011 11 26 http 1471-244X 11 26 BMC Psychiatry RESEARCH ARTICLE Open Access Reduced antioxidant defense in early onset first-episode psychosis a case-control study Juan Antonio Micó1 Maria Olga Rojas-Corrales1 Juan Gibert-Rahola1 Mara Parellada2 Dolores Moreno2 Cmz-Ii I r 3 h ỉ ỉ V c V I I4 I ỉz f rd I 15 I If 71 I 5 I c z Pi V r Cz I I r 6 V c I I f i 11 I 7 David Fraguas Montserrat Graell Javier Gil Jon Irazusta Josefina Castro-Fornieles Cesar Soutullo Celso Arango2 Soraya Otero8 Ana Navarro9 Inmaculada Baeza6 Mónica Martínez-Cengotitabengoa9 Ana González-Pinto10 Abstract Background Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group. Methods Total antioxidant status TAS and lipid peroxidation LOOH were determined in plasma. Enzyme activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first psychotic episode and 98 healthy controls. Results A decrease in antioxidant defense was found in patients measured as decreased TAS and glutathione levels. Lipid damage LOOH and glutathione peroxidase activity was higher in patients than controls. Our study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients. Conclusions Glutathione deficit seems to be implicated in psychosis and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia. Oxidative damage is present in these patients and may contribute to its pathophysiology. Background Oxidative stress-induced impairment of neuronal processes has been reported to be involved in neurodegeneration 1 and also in the pathophysiology of neuropsychiatric diseases such as schizophrenia 2-6 . It represents an imbalance between the oxidant molecules and the antioxidant defense system and generally occurs as a consequence of increased .