tailieunhanh - Báo cáo hóa học: " Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice | Yoshida et al. Nanoscale Research Letters 2011 6 195 http content 6 1 195 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice t Tokuyuki Yoshida Yasuo Yoshioka Maho Fujimura Kohei Yamashita Kazuma Higashisaka 2 2 Yuki Morishita Hiroyuki Kayamuro Hiromi Nabeshi Kazuya Nagano Yasuhiro Abe Haruhiko Kamada 2 3 4 1 12 -I- Shin-ichi Tsunoda Norio Itoh Tomoaki Yoshikawa Yasuo Tsutsumi Abstract With the increase in use of nanomaterials there is growing concern regarding their potential health risks. However few studies have assessed the role of the different physical characteristics of nanomaterials in allergic responses. Here we examined whether intranasally administered silica particles of various sizes have the capacity to promote allergic immune responses in mice. We used nanosilica particles with diameters of 30 or 70 nm nSP30 or nSP70 respectively and conventional micro-sized silica particles with diameters of 300 or 1000 nm nSP300 or mSP1000 respectively . Mice were intranasally exposed to ovalbumin OVA plus each silica particle and the levels of OVA-specific antibodies Abs in the plasma were determined. Intranasal exposure to OVA plus smaller nanosilica particles tended to induce a higher level of OVA-specific immunoglobulin Ig E IgG and IgG1 Abs than did exposure to OVA plus larger silica particles. Splenocytes from mice exposed to OVA plus nSP30 secreted higher levels of Th2-type cytokines than mice exposed to OVA alone. Taken together these results indicate that nanosilica particles can induce allergen-specific Th2-type allergic immune responses in vivo. This study provides the foundations for the establishment of safe and effective forms of nanosilica particles. Introduction With the recent development of nanotechnology many nanomaterials with innovative functions have .