tailieunhanh - Báo cáo y học: " Treatment patterns associated with Duloxetine and Venlafaxine use for Major Depressive Disorder"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Treatment patterns associated with Duloxetine and Venlafaxine use for Major Depressive Disorder | Ye et al. BMC Psychiatry 2011 11 19 http 1471 -244X 11 19 BMC Psychiatry RESEARCH ARTICLE Open Access Treatment patterns associated with Duloxetine and Venlafaxine use for Major Depressive Disorder Wenyu Ye1 Yang Zhao1 Rebecca L Robinson1 Ralph W Swindle2 Abstract Background Duloxetine and venlafaxine extended release venlafaxine XR are SNRIs indicated for the treatment of MDD. This study addresses whether duloxetine and venlafaxine XR are interchangeable in their patterns of use with patients who are depressed or are used more selectively based on treatment history background characteristics and presenting symptoms. Methods This was a retrospective analysis of an administrative insurance claims database. We studied patients in managed care with major depressive disorder MDD treated with duloxetine or venlafaxine XR. Predictors of treatment and cost were assessed using Chi-square and logistic regression analyses of demographics and past-year medication use and comorbidities. Results Patients with MDD treated with duloxetine n 9 641 versus venlafaxine XR n 8 514 tended to be older slightly more likely to be female and treated by a psychiatrist P . In the prior year more duloxetine patients vs. venlafaxine XR received 3 unique antidepressants vs. 3 unique pain medications vs. and had 8 unique diagnosed comorbid medical and psychiatric conditions vs. . The prior 6-month total health care costs were 1 731 higher for duloxetine than for venlafaxine XR and declined for both medications in the 6 months after treatment began. Logistic regression analysis revealed that 61 of duloxetine patients and 61 of venlafaxine XR patients were predictable from prior patient and treatment factors. Conclusions Patients with MDD treated with duloxetine tended to have a more complex and costly antecedent clinical presentation compared with venlafaxine XR patients suggesting that physicians do not use the medications .

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