tailieunhanh - Báo cáo y học: " Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder | Tadic et al. BMC Psychiatry 2011 11 16 http 1471-244X 11 16 BMC Psychiatry STUDY PROTOCOL Open Access Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder 1Ỷ 1 Ỷ 2 1 4 André Tadic Stefanie Wagner Stanislav Gorbulev Norbert Dahmen Christoph Hiemke Dieter F Braus Klaus Lieb1 Abstract Background In Major Depressive Disorder MDD treatment outcomes with currently available strategies are often disappointing. Therefore it is sensible to develop new strategies to increase remission rates in acutely depressed patients. Many studies reported that true drug response can be observed within 14 days early improvement of antidepressant treatment. The identical time course of symptom amelioration after early improvement in patients treated with antidepressants of all classes or with placebo strongly suggests a common biological mechanism which is not specific for a particular antidepressant medication. However the biology underlying early improvement and final treatment response is not understood and there is no established biological marker as yet which can predict treatment response for the individual patient before initiation or during the course of antidepressant treatment. Peripheral blood markers and executive functions are particularly promising candidates as markers for the onset of action and thus the prediction of final treatment outcome in MDD. Methods Design The present paper presents the rationales objectives and methods of a multi-centre study applying close-meshed repetitive measurements of peripheral blood and neuropsychological parameters in patients with MDD and healthy controls during a study period of eight weeks for the identification of biomarkers for the onset of antidepressants action in patients with MDD. Peripheral blood parameters and depression severity are assessed in weekly intervals from baseline to week 8 executive performance in .