tailieunhanh - Báo cáo y học: " Medio-Frontal and Anterior Temporal abnormalities in children with attention deficit hyperactivity disorder (ADHD) during an acoustic antisaccade task as revealed by electro-cortical source reconstruction"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Medio-Frontal and Anterior Temporal abnormalities in children with attention deficit hyperactivity disorder (ADHD) during an acoustic antisaccade task as revealed by electro-cortical source reconstruction | Goepel et al. BMC Psychiatry 2011 11 7 http 1471-244X 11 7 BMC Psychiatry RESEARCH ARTICLE Open Access Medio-Frontal and Anterior Temporal abnormalities in children with attention deficit hyperactivity disorder ADHD during an acoustic antisaccade task as revealed by electro-cortical source reconstruction Johanna Goepel Johanna Kissler Brigitte Rockstroh Isabella Paul-Jordanov Abstract Background Attention Deficit Hyperactivity Disorder ADHD is one of the most prevalent disorders in children and adolescence. Impulsivity is one of three core symptoms and likely associated with inhibition difficulties. To date the neural correlate of the antisaccade task a test of response inhibition has not been studied in children with or without ADHD. Methods Antisaccade responses to visual and acoustic cues were examined in nine unmedicated boys with ADHD mean age months and 14 healthy control children mean age months three girls while an electroencephalogram EEG was recorded. Brain activity before saccade onset was reconstructed using a 23-source-montage. Results When cues were acoustic children with ADHD had a higher source activity than control children in Medio-Frontal Cortex MFC between -230 and -120 ms and in the left-hemispheric Temporal Anterior Cortex TAC between -112 and 0 ms before saccade onset despite both groups performing similarly behaviourally antisaccades errors and saccade latency . When visual cues were used EEG-activity preceding antisaccades did not differ between groups. Conclusion Children with ADHD exhibit altered functioning of the TAC and MFC during an antisaccade task elicited by acoustic cues. Children with ADHD need more source activation to reach the same behavioural level as control children. Background Children with ADHD have difficulties with cognitive control working memory and response inhibition 1 . Response inhibition consists of two processes i the capacity to suppress a prepotent response .