tailieunhanh - Báo cáo y học: " RESEARCH ARTICLE Open Access One-year risk of psychiatric hospitalization and associated treatment costs in bipolar disorder treated with atypical antipsychotics: a retrospective claims database analysis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: One-year risk of psychiatric hospitalization and associated treatment costs in bipolar disorder treated with atypical antipsychotics: a retrospective claims database analysis | Kim et al. BMC Psychiatry 2011 11 6 http 1471-244X 11 6 BMC Psychiatry RESEARCH ARTICLE Open Access One-year risk of psychiatric hospitalization and associated treatment costs in bipolar disorder treated with atypical antipsychotics a retrospective claims database analysis Edward Kim1 Min You1 Andrei Pikalov2 Quynh Van-Tran2 Yonghua Jing1 Abstract Background This study compared 1-year risk of psychiatric hospitalization and treatment costs in commercially insured patients with bipolar disorder treated with aripiprazole ziprasidone olanzapine quetiapine or risperidone. Methods This was a retrospective propensity score-matched cohort study using the Ingenix Lab Rx integrated insurance claims dataset. Patients with bipolar disorder and 180 days of pre-index enrollment without antipsychotic exposure who received atypical antipsychotic agents were followed for up to 12 months following the initial antipsychotic prescription. The primary analysis used Cox proportional hazards regression to evaluate timedependent risk of hospitalization adjusting for age sex and pre-index hospitalization. Generalized gamma regression compared post-index costs between treatment groups. Results Compared to aripiprazole ziprasidone olanzapine and quetiapine had higher risks for hospitalization hazard ratio and respectively p risperidone had a numerically higher but not statistically different risk hazard ratio p . Mental health treatment costs were significantly lower for aripiprazole compared with ziprasidone p and quetiapine p but not compared to olanzapine p or risperidone p . Total healthcare costs were significantly lower for aripiprazole compared to quetiapine p but not other comparators. Conclusions In commercially insured adults with bipolar disorder followed for 1 year after initiation of atypical antipsychotics treatment with aripiprazole was associated with a lower risk of psychiatric hospitalization .