tailieunhanh - Báo cáo y học: "The genetics of acute lung injury: looking back and pointing the way forward"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:The genetics of acute lung injury: looking back and pointing the way forward. | Available online http content 13 1 108 Commentary The genetics of acute lung injury looking back and pointing the way forward Ednan K Bajwa Pulmonary and Critical Care Unit Massachusetts General Hospital Harvard Medical School Bulfinch 148 55 Fruit Street Boston MA 02114 USA Corresponding author Ednan K Bajwa ebajwa@ Published 12 January 2009 This article is online at http content 13 1 108 2009 BioMed Central Ltd Critical Care 2009 13 108 doi cc7132 See related research by Flores et al. http content 12 6 R130 Abstract Individual genetic factors have long been suspected of playing a major role in susceptibility to acute lung injury and acute respiratory distress syndrome. Flores and colleagues evaluate the quality of published studies testing the relationships between variation in candidate genes and susceptibility to lung injury syndromes or worsened outcome in patients with these conditions. Their results demonstrate that while important advances have been made in this area attention should be paid to improving the methodology of future studies in order to minimize the chances of publishing falsepositive results. In the previous issue of Critical Care Dr Flores and colleagues travel down a familiar path 1 . Throughout the history of medicine physicians have wondered how to account for the fact that individuals may respond so differently to similar illnesses. Indeed some of these relationships are obvious - patients who do not receive antibiotics in a timely fashion may progress rapidly from infection to septic shock 2 an older patient may be more likely to die than a younger healthier patient with the same illness 3 . Many a physician however has been left to wonder why given two relatively similar patients with community-acquired pneumonia one patient may recover quickly with a standard course of antibiotics while another patient develops catastrophic acute lung injury with its attendant profound hypoxemia .