tailieunhanh - Báo cáo y học: "Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients. | Available online http content 1 2 6 R147 Research Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients Philipp Kumpers1 Alexander Lukasz1 Sascha David1 Rudiger Horn2 Carsten Hafer1 Robert Faulhaber-Walter1 Danilo Fliser3 Hermann Haller1 and Jan T Kielstein1 Open Access 1 Department of Nephrology Hypertension Hannover Medical School Carl-Neuberg-Strasse 1 Hannover D-30171 Germany 2Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Carl-Neuberg-Strasse 1 Hannover D-30171 Germany 3Renal and Hypertensive Diseases Saarland University Medical Centre Kirrberger StraBe D-66421 Homburg Saar Germany Corresponding author Philipp Kumpers Received 22 Aug 2008 Revisions requested 19 Sep 2008 Revisions received 27 Oct 2008 Accepted 21 Nov 2008 Published 21 Nov 2008 Critical Care 2008 12 R147 doi cc7130 This article is online at http content 12 6 R1 47 2008 Kumpers et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The endothelial specific angiopoietin Ang -Tie2 ligand-receptor system has been identified as a non-redundant mediator of endothelial activation in experimental sepsis. Binding of circulating Ang-1 to the Tie2 receptor protects the vasculature from inflammation and leakage whereas binding of Ang-2 antagonises Tie2 signalling and disrupts endothelial barrier function. Here we examine whether circulating Ang-1 and or Ang-2 independently predict mortality in a cohort of critically ill medical patients. Methods Circulating vascular endothelial growth factor VEGF Ang-1 and Ang-2 were prospectively measured in sera from 29 healthy controls and 43 medical ICU .