tailieunhanh - Báo cáo y học: " Is there a linear relationship between the Brief Psychiatric Rating Scale and the Clinical Global Impression-Schizophrenia scale? "

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Is there a linear relationship between the Brief Psychiatric Rating Scale and the Clinical Global Impression-Schizophrenia scale? | Sawamura et al. BMC Psychiatry 2010 10 105 http 1471-244X 10 105 BMC Psychiatry RESEARCH ARTICLE Open Access Is there a linear relationship between the Brief Psychiatric Rating Scale and the Clinical Global Impression-Schizophrenia scale A retrospective analysis Jitsuki Sawamura1 Shigeru Morishita2 Jun Ishigooka1 Abstract Background Although the Brief Psychiatric Rating Scale BPRS is widely used for evaluating patients with schizophrenia it has limited value in estimating the clinical weight of individual symptoms. The aim of this study was 4-fold 1 to investigate the relationship of the BPRS to the Clinical Global Impression-Schizophrenia Scale CGI-SCH 2 to express this relationship in mathematical form 3 to seek significant symptoms and 4 to consider a possible modified BPRS subscale. Methods We evaluated 150 schizophrenia patients using the BPRS and the CGI-SCH then examined the scatter plot distribution of the two scales and expressed it in a mathematical equation. Next backward stepwise regression was performed to select BPRS items that were highly associated with the CGI-SCH. Multivariate regression was conducted to allocate marks to individual items proportional to their respective magnitude. We assessed the influence of modifications to the BPRS in terms of Pearson s r correlation coefficient and r-squared to evaluate the relationship between the two scales. Utilizing symptom weighting we assumed a possible BPRS subscale. Results By plotting the scores for the two scales a logarithmic curve was obtained. By performing a logarithmic transformation of the BPRS total score the curve was modified to a linear distribution described by CGI-SCH X log10 18-item BPRS - p . Pearson s r for the relationship between the scales was and r-squared was both p . Applying backward stepwise regression using small sets of items eight symptoms were positively correlated with the CGI-SCH p and the subset gave .