tailieunhanh - Báo cáo y học: "Prophylactic antibiotic treatment is superior to therapy on-demand in experimental necrotising pancreatitis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Prophylactic antibiotic treatment is superior to therapy on-demand in experimental necrotising pancreatitis. | Available online http content 1 2 6 R141 Research Prophylactic antibiotic treatment is superior to therapy on-demand in experimental necrotising pancreatitis Stefan Fritz1 Werner Hartwig1 Ronny Lehmann1 Katja Will-Schweiger2 Mechthild Kommerell2 Thilo Hackert1 Lutz Schneider1 Markus W Buchler1 and Jens Werner1 Open Access Department of General and Visceral Surgery University of Heidelberg Im Neuenheimer Feld 110 69120 Heidelberg Germany 2Section Infectiology Institute of Hygiene University of Heidelberg Im Neuenheimer Feld 324 691 20 Heidelberg Germany Corresponding author Jens Werner Received 13 May 2008 Revisions requested 26 Jun 2008 Revisions received 9 Oct 2008 Accepted 16 Nov 2008 Published 16 Nov 2008 Critical Care 2008 12 R141 doi cc7118 This article is online at http content 12 6 R1 41 2008 Fritz et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction High morbidity and mortality rates in patients with severe acute pancreatitis are mainly caused by bacterial superinfection of pancreatic necrosis and subsequent sepsis. The benefit of early prophylactic antibiotics remains controversial because clinical studies performed to date were statistically underpowered. Thus the aim of this study was to evaluate on-demand versus prophylactic antibiotic treatment in a standardised experimental model. Methods Treatment groups received meropenem either therapeutically 24 hours after induction of necrotising pancreatitis or prophylactically before development of pancreatic superinfection. At 24 and 72 hours pancreatic injury was investigated by histology and translocation by bacterial cultures of pancreatic tissue and mesenteric lymph nodes. .