tailieunhanh - Báo cáo y học: " Depression in Primary care: Interpersonal Counseling vs Selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. "

vbepression in Primary care: Interpersonal Counseling vs Selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. | Menchetti et al. BMC Psychiatry 2010 10 97 http 1471-244X 10 97 BMC Psychiatry STUDY PROTOCOL Open Access Depression in Primary care Interpersonal Counseling vs Selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design 1 1 1 1 Marco Menchetti Biancamaria Bortolotti Paola Rucci Paolo Scocco Annarosa Bombi Domenico Berardi DEPICS Study Group Abstract Background Depression is a frequently observed and disabling condition in primary care mainly treated by Primary Care Physicians with antidepressant drugs. Psychological interventions are recommended as first-line treatment by the most authoritative international guidelines but few evidences are available on their efficacy and effectiveness for mild depression. Methods Design This multi-center randomized controlled trial was conducted in 9 Italian centres with the aim to compare the efficacy of Inter-Personal Counseling a brief structured psychological intervention to that of Selective Serotonin Reuptake Inhibitors. Patients with depressive symptoms referred by Primary Care Physicians to psychiatric consultation-liaison services were eligible for the study if they met the DSM-IV criteria for major depression had a score 13 on the 21-item Hamilton Depression Rating Scale and were at their first or second depressive episode. The primary outcome was remission of depressive symptoms at 2-months defined as a HDRS score 7. Secondary outcome measures were improvement in global functioning and recurrence of depressive symptoms at 12-months. Patients who did not respond to Inter-Personal Counseling or Selective Serotonin Reuptake Inhibitors at 2-months received augmentation with the other treatment. Discussion This trial addresses some of the shortcomings of existing trials targeting major depression in primary care by evaluating the comparative efficacy of a brief psychological intervention that could be easily disseminated by .