tailieunhanh - Báo cáo y học: "A prospective trial of elective extubation in brain injured patients meeting extubation criteria for ventilatory support: a feasibility study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A prospective trial of elective extubation in brain injured patients meeting extubation criteria for ventilatory support: a feasibility study. | Available online http content 1 2 6 R138 Open Access Research A prospective trial of elective extubation in brain injured patients meeting extubation criteria for ventilatory support a feasibility study Edward M Manno1 Alejandro A Rabinstein1 Eelco FM Wijdicks1 Allen W Brown2 William D Freeman5 Vivien H Lee1 Stephen D Weigand3 MarkT Keegan4 Daniel R Brown4 Francis X Whalen4 Tuhin K Roy4 and Rolf D Hubmayr5 Department of Neurology Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USA department of Physical Medicine and Rehabilitation Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USA department of Biostatistics Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USA department of Anesthesiology Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USA department of Neurology Mayo Clinic College of Medicine 4500 San Pablo Road Jacksonville FL 32224 USA Corresponding author Edward M Manno Received 20 Aug 2008 Revisions requested 22 Sep 2008 Revisions received 14 Oct 2008 Accepted 1 0 Nov 2008 Published 10 Nov 2008 Critical Care 2008 12 R138 doi cc7112 This article is online at http content 12 6 R138 2008 Manno et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction To assess the safety and feasibility of recruiting mechanically ventilated patients with brain injury who are solely intubated for airway protection and randomising them into early or delayed extubation and to obtain estimates to refine samplesize calculations for a larger study. The design is a singleblinded block randomised controlled trial. A single large academic medical centre is the setting. Methods Sixteen