tailieunhanh - Báo cáo y học: " Differential temporal profile of lowered blood glucose levels (3.5 to 6.5 mmol/l versus 5 to 8 mmol/l) in patients with severe traumatic brain injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Differential temporal profile of lowered blood glucose levels ( to mmol/l versus 5 to 8 mmol/l) in patients with severe traumatic brain injury. | Available online http content 1 2 4 R98 Research Differential temporal profile of lowered blood glucose levels to mmol l versus 5 to 8 mmol l in patients with severe traumatic brain injury Regula Meier1 Markus Béchir1 Silke Ludwig1 Jutta Sommerfeld1 Marius Keel2 Peter Steiger1 Reto Stocker1 and John F Stover1 1Surgical Intensive Care Medicine University Hospital Zuerich Raemistrasse 100 CH 8091 Zuerich Switzerland 2Department of Surgery Division of Trauma Surgery University Hospital Zuerich Raemistrasse 1 00 CH 8091 Zuerich Switzerland Corresponding author John F Stover Received 28 May 2008 Revisions requested 23 Jun 2008 Revisions received 14 Jul 2008 Accepted 4 Aug 2008 Published 4 Aug 2008 Critical Care 2008 12 R98 doi cc6974 This article is online at http content 12 4 R98 2008 2008 Meier et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Hyperglycaemia is detrimental but maintaining low blood glucose levels within tight limits is controversial in patients with severe traumatic brain injury because decreased blood glucose levels can induce and aggravate underlying brain injury. Methods In 228 propensity matched patients age sex and injury severity treated in our intensive care unit ICU from 2000 to 2004 we retrospectively evaluated the influence of different predefined blood glucose targets to versus 5 to 8 mmol l on frequency of hypoglycaemic and hyperglycaemic episodes insulin and norepinephrine requirement changes in intracranial pressure and cerebral perfusion pressure mortality and length of stay on the ICU. Results Mortality and length of ICU stay were similar in both blood glucose target groups. Blood