tailieunhanh - Báo cáo y học: "Urinary interleukin-18 does not predict acute kidney injury after adult cardiac surgery: a prospective observational cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Urinary interleukin-18 does not predict acute kidney injury after adult cardiac surgery: a prospective observational cohort study. | Available online http content 1 2 4 R96 Research Urinary interleukin-18 does not predict acute kidney injury after adult cardiac surgery a prospective observational cohort study Michael Haase1 2 Rinaldo Bellomo1 David Story3 Piers Davenport4 and Anja Haase-Fielitz1 2 Department of Intensive Care Austin Health Melbourne 145 Studley Rd Heidelberg 3084 Australia department of Nephrology and Intensive Care Medicine Charité University Medicine 1 Augustenburger Platz Berlin 13353 Germany department of Anaesthesiology Austin Health Melbourne 145 Studley Rd Heidelberg 3084 Australia 4Department of Medicine Monash Medical Centre 168 Clayton Rd Clayton 3168 Melbourne Australia Corresponding author Rinaldo Bellomo Received 19 May 2008 Revisions requested 7 Jul 2008 Revisions received 16 Jul 2008 Accepted 1 Aug 2008 Published 1 Aug 2008 Critical Care 2008 12 R96 doi cc6972 This article is online at http content 12 4 R96 2008 Haase et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Urinary interleukin-18 IL-18 measured during the immediate postoperative period could be a promising predictor of acute kidney injury following adult cardiac surgery. Methods In a single-centre prospective observational cohort study we enrolled 100 adult cardiac surgical patients undergoing cardiopulmonary bypass at a tertiary hospital. We measured the urinary concentration of IL-18 and creatinine preoperatively on arrival in the intensive care unit and 24 hours postoperatively. We assessed urinary IL-18 concentration and urinary IL-18 urinary creatinine ratio in relation to the postoperative development of acute kidney injury defined as an increase in .