tailieunhanh - Báo cáo y học: " Brain size and brain/intracranial volume ratio in major mental illness"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Brain size and brain/intracranial volume ratio in major mental illness | Reite et al. BMC Psychiatry 2010 10 79 http 1471-244X 10 79 BMC Psychiatry RESEARCH ARTICLE Open Access Brain size and brain intracranial volume ratio in major mental illness 1 2 1 1 1 3 Martin Reite Erik Reite Dan Collins Peter Teale Donald C Rojas Elliot Sandberg Abstract Background This paper summarizes the findings of a long term study addressing the question of how several brain volume measure are related to three major mental illnesses in a Colorado subject group. It reports results obtained from a large N collected and analyzed by the same laboratory over a multiyear period with visually guided MRI segmentation being the primary initial analytic tool. Methods Intracerebral volume ICV total brain volume TBV ventricular volume VV ventricular brain ratio VBR and TBV ICV ratios were calculated from a total of 224 subject MRIs collected over a period of 13 years. Subject groups included controls C N 89 and patients with schizophrenia SZ N 58 bipolar disorder BD N 51 and schizoaffective disorder SAD N 26 . Results ICV TBV and VV measures compared favorably with values obtained by other research groups but in this study did not differ significantly between groups. TBV ICV ratios were significantly decreased and VBR increased in the SZ and BD groups compared to the C group. The SAD group did not differ from C on any measure. Conclusions In this study TBV ICV and VBR ratios separated SZ and BD patients from controls. Of interest however SAD patients did not differ from controls on these measures. The findings suggest that the gross measure of TBV may not reliably differ in the major mental illnesses to a degree useful in diagnosis likely due to the intrinsic variability of the measures in question the differences in VBR appear more robust across studies. Differences in some of these findings compared to earlier reports from several laboratories finding significant differences between groups in VV and TBV may relate to phenomenological drift .