tailieunhanh - Báo cáo y học: "he adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospective, randomised laboratory investigation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospective, randomised laboratory investigation. | Available online http content 1 2 5 R125 Research The adenosine deaminase inhibitor erythro-9- 2-hydroxyl-3-nonyl -adenine decreases intestinal permeability and protects against experimental sepsis a prospective randomised laboratory investigation Nalan Kayhan1 Benjamin Funke2 Lars Oliver Conzelmann1 Harald Winkler2 Stefan Hofer2 Jochen Steppan2 Heinfried SchmidtA Hubert Bardenheuer2 Christian-Friedrich Vahl1 and Markus A Weigand2 3 Open Access Department of Thoracic and Cardiovascular Surgery University of Mainz Langenbeckstr. 1 55131 Mainz Germany 2Department of Anesthesiology University of Heidelberg Im Neuenheimer Feld 110 69120 Heidelberg Germany 3Department of Anesthesiology and surgical Intensive Care Medicine University hospital of GieBen and Marburg Campus GieBen Rudolf-Buchheim Strasse 7 35292 GieBen Germany Contributed equally A Deceased Corresponding author Markus A Weigand Received 8 May 2008 Revisions requested 21 May 2008 Revisions received 10 Sep 2008 Accepted 13 Oct 2008 Published 13 Oct 2008 Critical Care 2008 12 R125 doi cc7033 This article is online at http content 12 5 R1 25 2008 Kayhan et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The treatment of septic conditions in critically ill patients is still one of medicine s major challenges. Cyclic nucleotides adenosine and its receptors play a pivotal role in the regulation of inflammatory responses and in limiting inflammatory tissue destruction. The aim of this study was to verify the hypothesis that adenosine deaminase-1 and cyclic guanosine monophosphate-stimulated phosphodiesterase inhibition by erythro-9- 2-hydroxyl-3-nonyl -adenine could be beneficial

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