tailieunhanh - Báo cáo y học: " The potential role of appetite in predicting weight changes during treatment with olanzapine"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The potential role of appetite in predicting weight changes during treatment with olanzapine | Case et al. BMC Psychiatry 2010 10 72 http 1471-244X 10 72 BMC Psychiatry RESEARCH ARTICLE Open Access The potential role of appetite in predicting weight changes during treatment with olanzapine Michael Case 1 Tamas Treuer2 Jamie Karagianis3 Vicki Poole Hoffmann1 Abstract Background Clinically significant weight gain has been reported during treatment with atypical antipsychotics. It has been suggested that weight changes in patients treated with olanzapine may be associated with increased appetite. Methods Data were used from adult patients for whom both appetite and weight data were available from 4 prospective 12- to 24-week clinical trials. Patients appetites were assessed with Eating Behavior Assessment EBA Study 1 Platypus Appetite Rating Scale PARS Study 2 Eating Inventory EI Study 3 Food Craving Inventory FCI Study 3 and Eating Attitude Scale EAS Study 4 . Results In Studies 1 EBA and 4 EAS patients who reported overall score increases on appetite scales indicating an increase in appetite experienced the greatest overall weight gains. However in Studies 2 PARS and 3 EI FCI patients who reported overall score increases on appetite scales did not experience greater weight changes than patients not reporting score increases. Early weight changes 2-4 weeks were more positively correlated with overall weight changes than early or overall score changes on any utilized appetite assessment scale. No additional information was gained by adding early appetite change to early weight change in correlation to overall weight change. Conclusions Early weight changes may be a more useful predictor for long-term weight changes than early score changes on appetite assessment scales. Clinical Trials Registration This report represents secondary analyses of 4 clinical studies. Studies 1 2 and 3 were registered at http ct2 home under NCT00190749 NCT00303602 and NCT00401973 respectively. Study 4 predates the registration requirements for