tailieunhanh - Báo cáo y học: "Comparison of functional residual capacity and static compliance of the respiratory system during a positive end-expiratory pressure (PEEP) ramp procedure in an experimental model of acute respiratory distress syndrome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Comparison of functional residual capacity and static compliance of the respiratory system during a positive end-expiratory pressure (PEEP) ramp procedure in an experimental model of acute respiratory distress syndrome. | Available online http content 1 2 4 R91 Research Comparison of functional residual capacity and static compliance of the respiratory system during a positive end-expiratory pressure PEEP ramp procedure in an experimental model of acute respiratory distress syndrome Bernard Lambermont1 2 Alexandre Ghuysen1 3 Nathalie Janssen1 3 Philippe Morimont1 2 Gary Hartstein3 Paul Gerard1 4 and Vincent D Orio1 3 Hemodynamic Research Center HemoLiege University of Liege Belgium 2Medical Intensive Care Unit Department of Medicine University Hospital of Liege Belgium 3Emergency Care Department University Hospital of Liege Belgium 4Department of Statistics University of Liege Belgium Corresponding author Bernard Lambermont Received 11 Apr 2008 Revisions requested 11 Jun 2008 Revisions received 25 Jun 2008 Accepted 16 Jul 2008 Published 1 6 Jul 2008 Critical Care 2008 12 R91 doi cc6961 This article is online at http content 12 4 R91 2008 Lambermont et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Functional residual capacity FRC measurement is now available on new ventilators as an automated procedure. We compared FRC static thoracopulmonary compliance Crs and PaO2 evolution in an experimental model of acute respiratory distress syndrome ARDS during a reversed sequential ramp procedure of positive end-expiratory pressure PEEP changes to investigate the potential interest of combined FRC and Crs measurement in such a pathologic state. Methods ARDS was induced by oleic acid injection in six anesthetised pigs. FRC and Crs were measured and arterial blood samples were taken after induction of ARDS during a sequential ramp change of PEEP from 20 cm